918431-87-5

Basic information

• Product Name: BenzaMide, 3,5-dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-diMethyl-2H-pyran-4-yl)Methyl]-4-piperidinyl]Methyl]-, (+)-
• CAS NO: 918431-87-5
• Molecular Formula: C21H29Cl2FN2O2
• Molecular Weight: 431.3715632
• Mol File: 918431-87-5.mol

Chemical Properties

• Boiling Point: 510.1°C at 760 mmHg
• Flash Point: 262.3°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 1.6E-10mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: BenzaMide, 3,5-dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-diMethyl-2H-pyran-4-yl)Methyl]-4-piperidinyl]Methyl]-, (+)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, 3,5-dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-diMethyl-2H-pyran-4-yl)Methyl]-4-piperidinyl]Methyl]-, (+)-(918431-87-5)
• EPA Substance Registry System: BenzaMide, 3,5-dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-diMethyl-2H-pyran-4-yl)Methyl]-4-piperidinyl]Methyl]-, (+)-(918431-87-5)

Safety Data

• Hazardous Substances Data: 918431-87-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H29Cl2FN2O2/c1-20(2)12-15(3-8-28-20)13-26-6-4-21(24,5-7-26)14-25-19(27)16-9-17(22)11-18(23)10-16/h9-11,15H,3-8,12-14H2,1-2H3,(H,25,27)

Upstream product

• 34941-21-4 2,2-dimethyltetrahydro-2H-pyran-4-carbaldehyde 
• 918430-49-6 3,5-dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4-ylmethyl]-benzamide 
• 918431-94-4 tert-butyl 4-((3,5-dichlorobenzamido)methyl)-4-fluoropiperidine-1-carboxylate 

Relevant articles and documents

Design, synthesis, and evaluation of a novel 4-aminomethyl-4- fluoropiperidine as a T-type Ca2+ channel antagonist

The novel T-type antagonist (S)-5 has been prepared and evaluated in in vitro and in vivo assays for T-type calcium ion channel activity. Structural modification of the piperidine leads 1 and 2 afforded the fluorinated piperidine (S)-5, a potent and selec

4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS

The present invention is directed to 4-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channel