918431-87-5Relevant articles and documents
Design, synthesis, and evaluation of a novel 4-aminomethyl-4- fluoropiperidine as a T-type Ca2+ channel antagonist
Shipe, William D.,Barrow, James C.,Yang, Zhi-Qiang,Lindsley, Craig W.,Yang, F. Vivien,Schlegel, Kelly-Ann S.,Shu, Youheng,Rittle, Kenneth E.,Bock, Mark G.,Hartman, George D.,Tang, Cuyue,Ballard, Jeanine E.,Kuo, Yuhsin,Adarayan, Emily D.,Prueksaritanont, Thomayant,Zrada, Matthew M.,Uebele, Victor N.,Nuss, Cindy E.,Connolly, Thomas M.,Doran, Scott M.,Fox, Steven V.,Kraus, Richard L.,Marino, Michael J.,Graufelds, Valerie Kuzmick,Vargas, Hugo M.,Bunting, Patricia B.,Hasbun-Manning, Martha,Evans, Rose M.,Koblan, Kenneth S.,Renger, John J.
scheme or table, p. 3692 - 3695 (2009/04/07)
The novel T-type antagonist (S)-5 has been prepared and evaluated in in vitro and in vivo assays for T-type calcium ion channel activity. Structural modification of the piperidine leads 1 and 2 afforded the fluorinated piperidine (S)-5, a potent and selec
4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS
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Page/Page column 26, (2010/11/25)
The present invention is directed to 4-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channel