918502-74-6

Basic information

• Product Name: (+/-)-Enterodiol-13C3
• Synonyms: (+/-)-Enterodiol-13C3;rac Enterodiol-13C3;(2R,3R)-rel-2,3-Bis[(3-hydroxyphenyl)Methyl]-1,4-butanediol-13C3;(R*,R*)-(±)-2,3-Bis[(3-hydroxyphenyl)Methyl]-1,4-butanediol-13C3
• CAS NO: 918502-74-6
• Molecular Formula: C18H22O4
• Molecular Weight: 302.36488
• Product Categories: Apoptosis;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals
• Mol File: 918502-74-6.mol

Chemical Properties

• Melting Point: 174-176 °C
• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Acetone (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (+/-)-Enterodiol-13C3(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-Enterodiol-13C3(918502-74-6)
• EPA Substance Registry System: (+/-)-Enterodiol-13C3(918502-74-6)

Safety Data

• Hazardous Substances Data: 918502-74-6(Hazardous Substances Data)

Usage

Uses

Used in Cancer Research and Treatment:
(+/-)-Enterodiol-13C3 is used as a research compound for studying its potential effects on cancer cells. It has been found to inhibit colonic cancer cell growth by inducing cell cycle arrest and apoptosis, which are crucial processes in preventing the uncontrolled proliferation of cancer cells.
Used in Epidemiological Studies:
(+/-)-Enterodiol-13C3 is used as a biomarker in epidemiological studies to investigate the possible relationship between exposure to (+/-)-Enterodiol-13C3 and the reduced risk of breast cancer. This helps researchers understand the potential benefits of incorporating sesame lignans into the diet for cancer prevention.
Used in Drug Development:
(+/-)-Enterodiol-13C3 is used as a lead compound in drug development for the treatment of various types of cancer. Its ability to induce cell cycle arrest and apoptosis makes it a promising candidate for the development of new cancer therapies.
Used in Nutritional Research:
(+/-)-Enterodiol-13C3 is used as a research tool in nutritional studies to explore the health benefits of sesame lignans and their potential role in cancer prevention and other health-related applications.

Upstream product

• 918502-72-4 [7,7',9'-13C₃]enterolactone 
• 741283-61-4 3-methoxy[α-13C]benzyl iodide 
• 741283-54-5 3-methoxy[α-13C]benzyl alcohol 
• 741283-53-4 3-methoxy[carboxy-13C]benzoic acid 
• 741283-60-3 4-(3'-methoxy[α-13C]benzyl)dihydro-2(3H)-[carbonyl-13C]furanone 
• 741283-59-0 2-(3'-methoxy[α-13C]benzyl)-3-[cyano-13C]cyanopropan-1-ol 
• 741283-63-6 3x ¹³C enterolactone 
• 159528-75-3 3-methoxybenzo<13C>nitrile 

Relevant articles and documents

The synthesis of multiply 13C-labelled plant and mammalian lignans as internal standards for LC-MS and GC-MS analysis

The syntheses of multiply 13C-labelled derivatives of the two mammalian lignans, enterolactone and enterodiol, and two of their plant lignan precursors, secoisolariciresinol and matairesinol, are described. Three 13C atoms were incorporated into each lignan using potassium [ 13C]cyanide as the source for all of the 13C atoms. The compounds were prepared for use as internal standards in the LC-MS and GC-MS analysis of lignans. Copyright

SYNTHESIS OF 13C-LABELLED ESTROGEN ANALOGUES

There is provided a method of producing novel 13C-labelled estrogen analogues. The method preferably proceeds via an intermediate A or B or which is a mixture of (A) or (B): wherein a13C atom is located at one or more of positions 1, 2, 3 or 4 and wherein R is an optionally substituted alkane, alkene, alkyne or aryl group. Preferably R is -CH2Ph. An alternative preferred intermediate compound is 13C-resorcinol.