- Tricyclic indole-2-carboxylic acid derivatives
-
A tricyclic indole-2-carboxylic acid derivative represented by the formula 1: STR1 wherein X represents alkyl, halogen or cyano;R 1 represents hydrogen, or a protecting group of carboxyl group;W represents hydrogen, --CO 2 R 3i, --CONR 3i R 4i, --A--CO 2 R 3i or --A--CONR 3i R 4i, wherein --A-- represents alkylene and R 3i and R 4i independently represent hydrogen, alkyl, aryl or substituted aryl,or a pharmaceutically acceptable salt thereof, these compounds are selective antagonists of glycine binding site of the NMDA receptor.
- -
-
-