918825-10-2Relevant articles and documents
N - amino alkyl sulfonyl - 3 - pyridine carboxamide derivatives and their use in the preparation of medicament for treating cardiovascular disease in the application
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Paragraph 0040-0043, (2017/08/25)
The invention provides an N-aminoalkyl-3-pyridinecarboxamide derivative having a novel structure and pharmaceutically acceptable salts thereof. The compound can be used for treating cardiovascular and cerebrovascular diseases, such as cerebral apoplexy, Alzheimer disease and myocardial ischemia or hypertension and has no significant difference in drug efficacy compared to the clinically used drugs and low toxicity.
Integrin receptor antagonists
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, (2008/06/13)
This invention relates to novel heterocycle compounds including but not limited to 3-?3-?3-(imidazolin-2-yl amino)propyloxy!isoxazol-5-ylcarbonylamino!-2-(benzyloxycarbonylamino)-propionic acid, which are useful as antagonists of the αv β3 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion and the treatment of angiogenic disorders, inflammation, bone degradation, tumors, metastases, thrombosis, and other cell aggregation-related conditions.