Synthesis of chiral 3-substituted hexahydropyrroloindoline via intermolecular cyclopropanation
(Chemical Equation Presented) A new and efficient synthetic route to chiral 3-substituted hexahydropyrroloindoline 18 possessing absolute configurations in accordance with indole alkaloids has been developed from readily available L-tryptophan. The key step relies on the one-pot cascade reaction of oxazolidinone 17 with diazoester, which proceeds through intermolecular cyclopropanation, ring opening, and cyclization.
Song, Hao,Yang, Jun,Chen, Wei,Qin, Yong
p. 6011 - 6014
(2007/10/03)
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