- Hypersensitive azobenzenes: Facile synthesis of clickable and cleavable azo linkers with tunable and high reducibility
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The aim of this work is to show that by increasing the number of donor substituents in a donor/acceptor system, the sensitivity of the azobenzene linkage towards a reductive cleavage reaction can be enhanced to unprecedented high levels. For instance, in a triple-donor system, less than a second constitutes the half-life of the azo (NN) bond. Synthetic access to such redox active scaffolds is highly practical and requires only 1-2 synthetic steps. The fundamental molecular design is also adaptable. This is demonstrated through scaffold functionalization by azide, tetraethylene glycol, and biotin groups. The availability of the azide group is shown in a copper-free 'click' reaction suitable in context with protein conjugation and proteomics application. Finally, the clean nature of the scission process is demonstrated with the help of liquid chromatography coupled with mass analysis. This work, therefore, describes development of cleavable azobenzene linkers that can be accessed with synthetic ease, can be multiply functionalized, and show a clean and rapid response to mild reducing conditions.
- Eom, Taejun,Khan, Anzar
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supporting information
p. 420 - 424
(2020/01/30)
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- 1,3-Dihydroxybenzene derivatives and colorants containing said compounds
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1,3-Dihydroxybenzene derivatives of general formula (I) or (Ia) or physiologically tolerated, water-soluble thereof wherein R′1 denotes substituted pyridyl group, a pyrimidyl group, a group of formula (IIa) or (IIIa) and the dyeing agents for keratin fibers containing these compounds.
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- Methine compounds
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Methine compounds are described, which can be represented by general formula [Ic]: STR1
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- Oxidative hair dye compositions
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Oxidative hair dye composition containing as "para component" compounds of the formula: SPC1 Or their acid addition salts, in which: R1 is alkyl or hydroxyalkyl; R2 is hydrogen or hydroxyalkyl; R3 is hydrogen, alkyl, alkoxy or halogen; and R4 occupies any one of the remaining positions on the benzene radical and is hydrogen, alkyl, alkoxy or halogen; providing that R2 is hydrogen when R3 is alkyl, alkoxy or halogen and providing that at least two of R1, R2, R3 or R4 are other than hydrogen.
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