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3,5-BIS[(4-FLUOROPHENYL)METHYLENE]-1-METHYLTETRAHYDRO-4(1H)-PYRIDINONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 920030-35-9 Structure
  • Basic information

    1. Product Name: 3,5-BIS[(4-FLUOROPHENYL)METHYLENE]-1-METHYLTETRAHYDRO-4(1H)-PYRIDINONE
    2. Synonyms: 3,5-BIS[(4-FLUOROPHENYL)METHYLENE]-1-METHYLTETRAHYDRO-4(1H)-PYRIDINONE
    3. CAS NO:920030-35-9
    4. Molecular Formula: C20H17F2NO
    5. Molecular Weight: 325.35
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 920030-35-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3,5-BIS[(4-FLUOROPHENYL)METHYLENE]-1-METHYLTETRAHYDRO-4(1H)-PYRIDINONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3,5-BIS[(4-FLUOROPHENYL)METHYLENE]-1-METHYLTETRAHYDRO-4(1H)-PYRIDINONE(920030-35-9)
    11. EPA Substance Registry System: 3,5-BIS[(4-FLUOROPHENYL)METHYLENE]-1-METHYLTETRAHYDRO-4(1H)-PYRIDINONE(920030-35-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 920030-35-9(Hazardous Substances Data)

920030-35-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 920030-35-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,0,0,3 and 0 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 920030-35:
(8*9)+(7*2)+(6*0)+(5*0)+(4*3)+(3*0)+(2*3)+(1*5)=109
109 % 10 = 9
So 920030-35-9 is a valid CAS Registry Number.

920030-35-9Downstream Products

920030-35-9Relevant articles and documents

Disubstituted aryl compound and application thereof

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Paragraph 0121-0123, (2019/08/06)

The invention relates to bis-substituted aryl compounds and application thereof. The structure of the bis-substituted aryl compounds is disclosed as Formula I, II or III. The experimental verification detects that the bis-substituted aryl compounds can be

For anti-tumor N - methyl - 3, 5 - aryl methylene - 4 - piperidone and its quaternary ammonium salt derivatives

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Paragraph 0054-0056, (2017/10/13)

The invention relates to antitumor drugs and particularly relates to an anti-tumor N-methyl-3,5-diarylmethylene-4-piperidone and quaternary ammonium derivatives thereof. The preparation method comprises the following steps of carrying out Claisen-Schmidt

Synthesis, Antiproliferative, and Multidrug Resistance Reversal Activities of Heterocyclic α,β-Unsaturated Carbonyl Compounds

Sun, Ju-feng,Hou, Gui-ge,Zhao, Feng,Cong, Wei,Li, Hong-juan,Liu, Wen-shuai,Wang, Chunhua

, p. 534 - 541 (2016/10/06)

A series of heterocyclic α,β-unsaturated carbonyl compounds (1a-1d, 2a-2d, 3a-3d, 4a-3d, and 5a-5d) with 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore were synthesized for the development of anticancer and multidrug resistance reverting agents. The antiproliferative activities were tested against nine human cancer cell lines. Approximately 73% of the IC50 values were below 5 μm, while 35% of these figures were submicromolar, and compounds 3a-3d with 4-trifluoro methyl in the arylidene benzene rings were the most potent, since their IC50 values are between 0.06 and 3.09 μm against all cancer cell lines employed. Meanwhile, their multidrug resistance reversal properties and cellular uptake were further examined. The data displayed that all of these compounds could reverse multidrug resistance, particularly, compounds 3a and 4a demonstrated both potent multidrug resistance reverting properties and strong antiproliferative activities, which can be taken as leading molecules for further research of dual effect agents in tumor chemotherapy.

Synthesis and molecular modeling studies of indole-based antitumor agents

George, Riham F.,Panda, Siva S.,Shalaby, El-Sayed M.,Srour, Aladdin M.,Farag, I. S. Ahmed,Girgis, Adel S.

, p. 45434 - 45451 (2016/06/06)

Indole-based compounds 30-63 were synthesized by the multi-component 1,3-dipolar cycloaddition reaction of 1-alkyl-3,5-bis(arylidene)-4-piperidones 11-25 with azomethine ylides (generated by the condensation of isatins 26-28 with sarcosine 29). The single crystal X-ray studies of 46 and 48 supported the regio- and stereoselectivity of the reaction. Most of the synthesized spiro-indoles exhibited potent antitumor properties against the HeLa (cervical cancer) cell line through in vitro sulfo-rhodamine-B bioassay, higher than that of cisplatin. Only compound 54 showed bio-potency against the HepG2 (hepatocellular cancer) cell line, comparable to that of doxorubicin hydrochloride (standard reference). 3D-Pharmacophore and 2D-QSAR studies were used to validate the observed biological data and determine the most important parameters controlling activity. The estimated bio-properties from the computational studies showed high approximations to the experimental data.

Design, synthesis, and antiproliferative activity assessment of non-ATP-competitive fibroblast growth factor receptor 1 inhibitors

Ying,Wang, Jia,Xu,Kang,Zhang,Shi,Fan,Wang,Zhou,Wu,Wu,Li,Liang

, p. 2744 - 2751 (2017/03/22)

Fibroblast growth factor receptor 1 (FGFR1) is considered a therapeutic target for multiple cancers, including gastric cancer. FGFR1 inhibitors, being ATP competitors, can prevent the kinase domain and the downstream signaling cascade from phosphorylation

Discovery and evaluation of piperid-4-one-containing mono-carbonyl analogs of curcumin as anti-inflammatory agents

Wu, Jianzhang,Zhang, Yali,Cai, Yuepiao,Wang, Jian,Weng, Bixia,Tang, Qinqin,Chen, Xiangjian,Pan, Zheer,Liang, Guang,Yang, Shulin

, p. 3058 - 3065 (2013/07/25)

We previously reported the design and discovery of three series of 5-carbon linker-containing mono-carbonyl analogs of curcumin (MCACs) as excellent anti-inflammatory agents. In continuation of our ongoing research, we designed and synthesized the fourth

Synthesis, cytotoxicity, and structure-activity insight of NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidones

Gregory, Matthew,Dandavati, Armaan,Lee, Megan,Tzou, Samuel,Savagian, Mia,Brien, Kimberly A.,Satam, Vijay,Patil, Pravin,Lee, Moses

, p. 5588 - 5597 (2013/12/04)

Twenty-one NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidone analogs of curcumin, 12 of which are novel, were synthesized and evaluated for their cytotoxicity against B16 (murine melanoma) and L1210 (murine lymphoma) cells grown in culture. These curcumi

Magnetic graphene oxide anchored sulfonic acid as a novel nanocatalyst for the synthesis of N-aryl-2-amino-1,6-naphthyridines

Rostamizadeh, Shahnaz,Rezgi, Mina,Shadjou, Nasrin,Hasanzadeh, Mohammad

, p. 1317 - 1322 (2014/04/17)

Magnetic graphene oxide functionalized with sulfonic acid (Fe 3O4-GO-SO3H) was used as a new recyclable nanocatalyst for one-pot synthesis of N-aryl-2-amino-1,6-naphthyridine derivatives under solvent free conditions. The catalyst could be easily recovered from the reaction mixture by an external magnet and reused without significant decrease in activity even after 4 runs. This nanocatalyst exhibited better activities to other commercially available sulfonic acid catalysts.

Application of MCM-41-SO3H as an advanced nanocatalyst for the solvent free synthesis of pyrano[3,2-c]pyridine derivatives

Rostamizadeh, Shahnaz,Shadjou, Nasrin,Hasanzadeh, Mohammad

experimental part, p. 866 - 871 (2012/08/07)

MCM-41-SO3H, an ordered mesoporous silica material in which MCM-41 with covalently anchored sulfonic acid groups was used as an acidic catalyst for the rapid and 'green' synthesis of pyrano[3,2-c]pyridine derivatives under solvent-free conditions. Reusability of the catalyst, high yields, short reaction times, simplicity and easy workup are advantages of this novel synthetic procedure compared to the conventional methods reported in the literature.

Lewis acids as mild and effective catalysts for the synthesis of 3,5-bis[(hetero)arylidene]piperidin-4-ones

Leonova, Evgeniya,Makarov, Mihail,Klemenkova, Zinaida,Odinets, Irina

experimental part, p. 1990 - 1999 (2010/12/25)

The aldol-crotonic condensation reactions of N-alkyl- and NH-piperidin-4-one derivatives with (hetero)aromatic aldehydes promoted by Lewis acids or bases were examined. This comparative study has revealed three effective catalytic systems based on Lewis a

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