920313-46-8

Basic information

• Product Name: 5-Thiazolepropanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-
• Synonyms: 5-Thiazolepropanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-
• CAS NO: 920313-46-8
• Molecular Formula: C₁₁H₁₆N₂O₄S
• Molecular Weight: 272.32
• Mol File: 920313-46-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Thiazolepropanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolepropanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-(920313-46-8)
• EPA Substance Registry System: 5-Thiazolepropanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-(920313-46-8)

Safety Data

• Hazardous Substances Data: 920313-46-8(Hazardous Substances Data)

Upstream product

• 883501-73-3 3-(2-Amino-thiazol-5-yl)-propionic acid methyl ester 
• 6026-86-4 methyl 4-formylbutanoate 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 

Downstream Products

• 936449-26-2 3-(2-Amino-thiazol-5-yl)-N-(3-fluoro-phenyl)-propionamide 

Relevant articles and documents

Thiazole analogues and uses thereof

The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, R2 is attached at the 4- or 5-position of the thiazole ring and is hydrogen, alkyl, halogen, cyano, alkoxy, haloalkyloxy, or alkylamino; X independently represents a divalent linkage group selected from S, O, NR4, SO, or SO2; R4 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, or heterocyclyl; is attached at the 4- or 5-position of the thiazole ring and independently represents one of the following groups of the general formula (II): wherein the dotted line represents a single or double bond; * indicates the point of attachment to the thiazole ring; n is 1,2, or 3.

Thiazole Analogues and Uses Thereof

Compounds of formula (I) and salts and physiologically functional derivatives thereof, wherein R2 is attached at the 4- or 5-position of the thiazole ring and is hydrogen, alkyl, halogen, cyano, alkoxy, haloalkoxy, or alkylamino; X independently represents a divalent linkage group selected from S, O, NR4, SO, or SO2; R4 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, or heterocyclyl; R1 is attached at the 4- or 5-position of the thiazole ring and independently represents a group of formula (II): ?wherein the dotted line represents a single or double bond; * indicates the point of attachment to the thiazole ring; and n is 1, 2, or 3. Also disclosed are pharmaceutical compositions comprising the above compounds and method of treatments for cancer and other diseases.