920338-58-5Relevant articles and documents
Chemical transformations of 3-aminopyrrolidin-2-ones of the norbornane and cyclopropane series
Kostyuchenko,Shulishov,Rafikov,Novichkov,Dokichev,Tomilov
scheme or table, p. 339 - 346 (2010/07/08)
3-Aminopyrrolidin-2-ones containing a fused norbornane or spirocyclopropane fragment react with benzaldehyde to give azomethines, which can be transformed into N-substituted 3-aminopyrrolidin-2-ones by reduction with sodium borohydride. Diazotization of amino-pyrrolidinones with NaNO2 in acetic acid results in the elimination of molecular nitrogen and in the formation of acetoxy or unsaturated derivatives (through stabilization of intermediate carbocations). 6-Methylidene4-azaspiro[2.4]heptan-5-one obtained by diazotization of 6-amino-6-methyl-4-azaspiro[2.4]heptan-5-one easily reacts with diazomethane, diazocyclo-propane, and benzonitrile oxide to yield heterocyclic spiranes by means of 1,3-dipolar cycloaddition.
Reduction of substituted spiro[cyclopropane-3-(1-pyrazolines)] to spiro[cyclopropane-3-pyrazolidines] and 1-(2-aminoethyl)cyclopropylamine derivatives
Kostyuchenko,Shulishov,Korolev,Dokichev,Tomilov
, p. 2562 - 2570 (2007/10/03)
Raney nickel-catalyzed hydrogenation of 5-substituted spiro[cyclopropane-3- (1-pyrazoline)]-5-carboxylates occurs with N-N bond cleavage with simultaneous cyclocondensation to give 3-aminopyrrolidin-2-ones containing a spirocyclopropane fragment. The pres
