Flexible strategy for differentially 3,5-disubstituted 4-oxypyridin-2(1H)- ones based on site-selective Pd-catalyzed cross-coupling reactions
(Chemical Equation Presented) 3,5-Dihalogeno-4-methoxy-N-methylpyridin- 2(1H)-ones have been shown to undergo single Suzuki coupling reactions in a site-selective fashion. Monoarylations occur at the C-5 position preferentially, thus leaving the remaining