920966-01-4

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-1-[tris(1-methylethyl)silyl]-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-1-[tris(1-methylethyl)silyl]-;4-chloro-1-tri(propan-2-yl)silylpyrrolo[2,3-b]pyridine-5-carbonitrile
• CAS NO: 920966-01-4
• Molecular Formula: C17H24ClN3Si
• Molecular Weight: 333.93
• Mol File: 920966-01-4.mol

Chemical Properties

• Boiling Point: 375.9°C at 760 mmHg
• Flash Point: 181.1°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 7.54E-06mmHg at 25°C
• Refractive Index: 1.551
• PKA: 2.28±0.30(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-1-[tris(1-methylethyl)silyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-1-[tris(1-methylethyl)silyl]-(920966-01-4)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-1-[tris(1-methylethyl)silyl]-(920966-01-4)

Safety Data

• Hazardous Substances Data: 920966-01-4(Hazardous Substances Data)

Usage

Molecular Structure

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-1-[tris(1-methylethyl)silyl]features a complex structure with a pyrrolopyridine ring system, a carbonitrile group at position 5, and a chlorine atom at position 4.

Carbonitrile Group

The compound contains a carbonitrile group (C≡N) at the 5-position of the pyrrolopyridine ring, which is a key functional group that can participate in various chemical reactions and contributes to the compound's reactivity.

Chlorine Atom

A chlorine atom is present at the 4-position of the pyrrolopyridine ring, which can be used for further functionalization or as a handle for the synthesis of derivatives with altered properties.

Tris(1-methylethyl)silyl Group

The compound has a tris(1-methylethyl)silyl group attached to a silicon atom, which consists of three isopropyl (1-methylethyl) groups. This group can provide steric hindrance and influence the compound's reactivity and solubility.

Pharmaceutical Applications

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-1-[tris(1-methylethyl)silyl]has potential applications in pharmaceutical research and development due to its unique structure and functional groups, which can be utilized to create new drugs with specific therapeutic properties.

Synthesis of Organic Molecules

The compound can be used as a building block in the synthesis of other organic molecules, allowing for the creation of novel chemical compounds with useful properties.

Valuable Building Block

The detailed molecular structure of 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-chloro-1-[tris(1-methylethyl)silyl]makes it a valuable building block for the development of new chemical compounds, as its unique structure and functional groups can be exploited in various synthetic routes.

InChI:InChI=1/C17H24ClN3Si/c1-11(2)22(12(3)4,13(5)6)21-8-7-15-16(18)14(9-19)10-20-17(15)21/h7-8,10-13H,1-6H3

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 920966-02-5 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile 
• 19158-51-1 P-toluenesulfonyl cyanide 

Relevant articles and documents

JANUS KINASE (JAK) FAMILY INHIBITOR, PREPARATION OF SAME, AND APPLICATIONS THEREOF

A 7-azaindole derivative having the structure of formula (I), a pharmaceutical composition containing the compound of formula (I), and uses of the compound in preparing a medicament for preventing or treating Janus kinase (JAK) family-related diseases, specifically, uses in preventing or treating inflammatory diseases related to protein tyrosine kinase.

NOVEL COMPOUNDS

The invention relates to compound of the formula (I) or its salt, wherein -R1, -R2, -R3, -R4, -R5, -M-, -X- and -Y= are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases.