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92125-38-7

Withaperuvin E is a naturally occurring organic compound found in the roots of the plant Withania somnifera, commonly known as Ashwagandha. It belongs to the class of withanolides, which are a group of steroidal lactones with various pharmacological properties. Withaperuvin E has been studied for its potential anti-inflammatory, antioxidant, and neuroprotective effects, as well as its ability to modulate the immune system. Research on this compound is ongoing, and it holds promise for potential therapeutic applications in various health conditions, including neurological disorders and inflammation-related diseases.

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  • 92125-38-7 Structure

  • Basic information

    1. Product Name: withaperuvin E
    2. Synonyms: withaperuvin E;(17S,22R)-5,6β-Epoxy-14,17,20,22-tetrahydroxy-1,4-dioxo-5β-ergosta-2,24-dien-26-oic acid 26,22-lactone
    3. CAS NO:92125-38-7
    4. Molecular Formula: C28H36O8
    5. Molecular Weight: 500.58064
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 92125-38-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: withaperuvin E(CAS DataBase Reference)
    10. NIST Chemistry Reference: withaperuvin E(92125-38-7)
    11. EPA Substance Registry System: withaperuvin E(92125-38-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 92125-38-7(Hazardous Substances Data)

92125-38-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 92125-38-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,1,2 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 92125-38:
(7*9)+(6*2)+(5*1)+(4*2)+(3*5)+(2*3)+(1*8)=117
117 % 10 = 7
So 92125-38-7 is a valid CAS Registry Number.

92125-38-7Upstream product

92125-38-7Downstream Products

92125-38-7Relevant articles and documents

WITHAPERUVIN E AND NICANDRIN B, WITHANOLIDES FROM PHYSALIS PERUVIANA AND NICANDRA PHYSALOIDES

Bagghi, Anjana,Neogi, Partha,Sahai, Mahendra,Ray, Anil B.,Oshima, Yoshiteru,Hikino, Hiroshi

, p. 853 - 856 (1984)

Novel withanolides, withaperuvin E and nicandrin B, isolated from Physalis peruviana and Nicandra physaloides, were fully characterized by chemical and spectroscopic means.Key Word Index - Physalis peruviana; Nicandra physaloides; Solanaceae; withanolides; withaperuvin E; nicandrin B.

17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships

Xu, Ya-Ming,Brooks, Alan D.,Wijeratne, E. M. Kithsiri,Henrich, Curtis J.,Tewary, Poonam,Sayers, Thomas J.,Gunatilaka, A. A. Leslie

, p. 3039 - 3051 (2017/04/21)

Renal cell carcinoma (RCC) is a cancer with poor prognosis, and the 5-year survival rate of patients with metastatic RCC is 5-10%. Consequently, treatment of metastatic RCC represents an unmet clinical need. Screening of a 50 000-member library of natural and synthetic compounds for sensitizers of RCC cells to TRAIL-mediated apoptosis led to identification of the 17β-hydroxywithanolide (17-BHW), withanolide E (1), as a promising lead. To explore structure-activity relationships, we obtained natural and semisynthetic withanolides 1, 2a, 2c, and 3-36 and compared their ability to sensitize TRAIL-mediated apoptosis in a panel of renal carcinoma cells. Our findings revealed that 17-BHWs with a α-oriented side chain are superior to known TRAIL-sensitizing withanolides belonging to withaferin A class with a β-oriented side chain and demonstrated that the 17-BHW scaffold can be modified to enhance sensitization of RCCs to TRAIL-mediated apoptosis, thereby assisting development of natural-product-inspired drugs to treat metastatic RCC.

METHOD OF SENSITIZING CANCER CELLS TO THE CYTOTOXIC EFFECTS OF APOPTOSIS INDUCING LIGANDS IN CANCER TREATMENT

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Paragraph 0190; 0191, (2017/09/05)

Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R1-R14 are as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells.

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