Decarboxylative fluorination of aliphatic carboxylic acids via photoredox catalysis
The direct conversion of aliphatic carboxylic acids to the corresponding alkyl fluorides has been achieved via visible light-promoted photoredox catalysis. This operationally simple, redox-neutral fluorination method is amenable to a wide variety of carboxylic acids. Photon-induced oxidation of carboxylates leads to the formation of carboxyl radicals, which upon rapid CO2-extrusion and F? transfer from a fluorinating reagent yield the desired fluoroalkanes with high efficiency. Experimental evidence indicates that an oxidative quenching pathway is operable in this broadly applicable fluorination protocol.
Ventre, Sandrine,Petronijevic, Filip R.,Macmillan, David W. C.
supporting information
p. 5654 - 5657
(2015/05/20)
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