921760-85-2

Basic information

• Product Name: 3,4-DIHYDRO-4-OXO-SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDINE]-1',6-DICARBOXYLIC ACID 1'-(1,1-DIMETHYLETHYL) ESTER
• Synonyms: 3,4-DIHYDRO-4-OXO-SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDINE]-1',6-DICARBOXYLIC ACID 1'-(1,1-DIMETHYLETHYL) ESTER;tert-Butyl 6-carboxy-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate
• CAS NO: 921760-85-2
• Molecular Formula: C19H23NO6
• Molecular Weight: 361.39
• Mol File: 921760-85-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-DIHYDRO-4-OXO-SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDINE]-1',6-DICARBOXYLIC ACID 1'-(1,1-DIMETHYLETHYL) ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIHYDRO-4-OXO-SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDINE]-1',6-DICARBOXYLIC ACID 1'-(1,1-DIMETHYLETHYL) ESTER(921760-85-2)
• EPA Substance Registry System: 3,4-DIHYDRO-4-OXO-SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDINE]-1',6-DICARBOXYLIC ACID 1'-(1,1-DIMETHYLETHYL) ESTER(921760-85-2)

Safety Data

• Hazardous Substances Data: 921760-85-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Dihydro-4-oxo-spiro[2H-1-benzopyran-2,4'-piperidine]-1',6-dicarboxylic acid 1'-(1,1-dimethylethyl) ester is used as a precursor in the synthesis of pharmaceutical compounds for its structural similarity to bioactive benzopyran and piperidine derivatives. Its unique structure may contribute to the development of new drugs with potential therapeutic benefits.
Used in Research and Development:
In the field of medicinal chemistry, 3,4-Dihydro-4-oxo-spiro[2H-1-benzopyran-2,4'-piperidine]-1',6-dicarboxylic acid 1'-(1,1-dimethylethyl) ester serves as a valuable research compound for studying its biological activities and exploring its potential as a lead molecule in drug discovery. This can aid in the advancement of novel therapeutic agents and contribute to the understanding of its pharmacological profile.

Upstream product

• 921760-84-1 4-oxospiro[chroman-2,4'-piperidine]-6-carboxylic acid hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

SPIROCHROMANON DERIVATIVES

The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of benzene, pyrazole, isoxazole, pyridine, indole, 1H-indazole, 1H-furo[2,3-c]pyrazole, 1H-thieno[2,3-c]pyrazole, benzimidazole, 1,2-benzisoxazole, imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine and 1H-pyrazolo[3,4-b]pyridine, having Ar2, and optionally having one or two or more substituents selected from R3; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; or a C1-C6 alkyl group optionally having a substituent; or an aryl or heterocyclic group optionally having a substituent; or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom or a sulfur atom. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.

SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS

The invention relates to a compound of a formula (I): , or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.