A general synthesis of 8-hydroxy-6-substituted-1,7-naphthyridines
A general method for the synthesis of 8-hydroxy-6-substituted-1,7- naphthyridines is described using acylation of the dianion derived from tert-butylamide 1, followed by cyclization of the resulting intermediate ketones 2 with ammonium acetate.
Jiang, Xinglong,Chen, Guang-Pei,Prasad, Kapa,Repic, Oljan,Blacklock, Thomas J.