923032-59-1

Basic information

• Product Name: 1-Allylcyclopropane-1-sulfonyl chloride
• Synonyms: 1-Allylcyclopropanesulfonyl chloride;1-Allylcyclopropane-1-sulfonyl chloride;1-(2-Propen-1-yl)cyclopropanesulfonyl Chloride;1-(prop-2-en-1-yl)cyclopropane-1-sulfonyl chloride
• CAS NO: 923032-59-1
• Molecular Formula: C6H9ClO2S
• Molecular Weight: 180.65
• Product Categories: sulfonyl compound;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfonyl Chlorides
• Mol File: 923032-59-1.mol

Chemical Properties

• Boiling Point: 229.2 °C at 760 mmHg
• Flash Point: 92.4 °C
• Appearance: yellow oil
• Density: 1.32 g/cm³
• Refractive Index: 1.515
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: Chlroform
• CAS DataBase Reference: 1-Allylcyclopropane-1-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Allylcyclopropane-1-sulfonyl chloride(923032-59-1)
• EPA Substance Registry System: 1-Allylcyclopropane-1-sulfonyl chloride(923032-59-1)

Safety Data

• Hazardous Substances Data: 923032-59-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Allylcyclopropane-1-sulfonyl chloride is used as a MEK inhibitor for its potential role in the treatment of cancer and other hyperproliferative diseases. As a MEK inhibitor, it can help regulate the MAPK/ERK signaling pathway, which is often dysregulated in cancer cells, leading to uncontrolled cell growth and proliferation. By inhibiting MEK, 1-Allylcyclopropane-1-sulfonyl chloride may contribute to the suppression of tumor growth and the management of various cancer types.
Additionally, 1-Allylcyclopropane-1-sulfonyl chloride may also be utilized in research settings to study the mechanisms of cell proliferation and the effectiveness of MEK inhibition in different biological contexts. This can aid in the development of novel therapeutic strategies and the identification of potential drug candidates for the treatment of various diseases characterized by abnormal cell proliferation.

InChI:InChI=1/C6H9ClO2S/c1-2-3-6(4-5-6)10(7,8)9/h2H,1,3-5H2

Upstream product

• 923032-56-8 butyl 1-allylcyclopropane-1-sulfonate 
• 923032-57-9 potassium 1-allylcyclopropane-1-sulfonate 

Relevant articles and documents

BIOMARKERS FOR DETERMINING EFFECTIVE RESPONSE OF TREATMENTS OF HEPATOCELLULAR CARCINOMA (HCC) PATIENTS

This invention is directed to the use of one or more biomarkers defined as KRAS or NRAS gene for predicting the pharmaceutical efficacy or clinical response of MEK protein kinase inhibitor and/or Sorafenib or Regorafenib to be administred to a Hepatocellu

COMBINATIONS OF MEK INHIBITORS AND RAF KINASE INHIBITORS AND USES THEREOF

This invention concerns combinations of inhibitors of MEK, Raf protein kinases, and other kinases including VEGFR1-3 and PDGFR-β. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer and other hyperproliferative disorders.

NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMIDES AS MEK INHIBITORS

The invention provides novel substituted 6-arylamino pyridone sulfonamides and 6 arylamino pyrazinone sulfonamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans

N-(ARYLAMINO)-SULFONAMIDE INHIBITORS OF MEK

This invention concerns N-(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.