- Synthesis of Aliphatic Carboxamides Mediated by Nickel NN2-Pincer Complexes and Adaptation to Carbon-Isotope Labeling
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The development of a nickel-mediated aminocarbonylation utilizing NN2-pincer Ni-complexes, alkylzinc reagents, stoichiometric carbon monoxide and amines is described for the first time, which can be adapted to late-stage carbon-isotope labeling. This work expands the scope of the highly established palladium-promoted version of the reaction, by allowing carbon-sp3 fragments to take part in the three-component reaction. Finally, the results obtained show a remarkable effect of the pincer ligand for the reductive elimination step with the amine, which is followed by 13C NMR spectroscopy studies.
- Neumann, Karoline T.,Donslund, Aske S.,Andersen, Thomas L.,Nielsen, Dennis U.,Skrydstrup, Troels
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