923595-58-8

Basic information

• Product Name: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
• Synonyms: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
• CAS NO: 923595-58-8
• Molecular Formula: C₆H₃ClIN₃
• Molecular Weight: 279.464
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 923595-58-8.mol

Chemical Properties

• Appearance: /
• Density: 2.346g/cm3
• Refractive Index: 1.832
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine(923595-58-8)
• EPA Substance Registry System: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine(923595-58-8)

Safety Data

• Hazardous Substances Data: 923595-58-8(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine is used as a building block in the synthesis of various biologically active molecules and pharmaceuticals. Its unique structure and functional groups make it a valuable component in the development of new drugs with specific therapeutic properties.
Used in Drug Discovery:
In the field of drug discovery, 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine serves as a key intermediate for the creation of novel compounds with potential therapeutic applications. Its presence in these molecules can influence their pharmacological activity, selectivity, and efficacy.
Used in Academic Research:
5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine is also utilized as a tool compound in academic research settings. Researchers use it to study the biological activity of pyrazolo[1,5-a]pyrimidine derivatives, gaining insights into their mechanisms of action and potential applications in medicine.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine is employed as a starting material for the development of new drugs. Its unique chemical properties and potential to be modified through various chemical reactions make it an attractive candidate for the synthesis of innovative therapeutic agents.
Used in Chemical Synthesis:
5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine is used as a key intermediate in chemical synthesis processes. Its reactivity and structural features allow for the creation of a wide range of compounds with diverse applications, including those in the fields of medicine, agriculture, and materials science.

InChI:InChI=1/C6H3ClIN3/c7-5-1-2-11-6(10-5)4(8)3-9-11/h1-3H

Upstream product

• 29274-24-6 5-chloropyrazolo[1,5-a]pyrimidine 
• 29274-22-4 pyrazolo[1,5-a]pyrimidine-5-ol 

Downstream Products

• 1621718-51-1 2,4-difluoro-N-(5-(3-(3-hydroxyprop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-2-methoxypyridin-3-yl)benzenesulfonamide 

Relevant articles and documents

FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS

The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases. In some compounds of Formula I, Q is —CH═CR3C(O)NR4R5, —C≡CC(O)NR4R5, or

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

The serine-threonine kinase CDK9 is a target of emerging interest for the development of anti-cancer drugs. There are multiple lines of evidence linking CDK9 activity to cancer, including the essential role this kinase plays in transcriptional regulation

HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE

The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

FUSED HETEROCYCLES AS LCK INHIBITORS

There is provided fused heterocycles of imidazopyridazine or pyrazolopyrimidine derivative represented by the formula (I), which have excellent Lck inhibitory activity and are useful for a medicament particularly an immunosuppressive agent. [wherein one of Y and Z is C atom, and the other is N atom; -X-10 is -N (R1) - or the like, -R1 is hydrogen or the like, -A- is bond or the like, is cycloalkyl, aryl or the like, -E- is bond or the like, -R3 is aryl, aromatic heterocycle or the like, -R4, -R5 and -R6 are the same or different, each being hydrogen or the like.]