This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.
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Paragraph 0205
(2016/04/26)
CYCLOPROPYL AMINE DERIVATIVES
Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compoun
Charette, André B.,Lebel, Hélène,Minbiole, Kevin,Verhoest, Patrick,Smith, Amos B.
p. 86 - 86
(2017/10/06)
Enantioselective cyclopropanation of allylic alcohols with dioxaborolane ligands: Scope and synthetic applications
A very effective chiral controller has been found for the conversion of allylic alcohols into the corresponding enantiomerically enriched cyclopropanes using bis(iodomethyl)zinc. A variety of chiral, nonracemic cyclopropylmethanols could be obtained according to this method. This methodology was extended with success to the cyclopropanation of unconjugated and conjugated polyenes and homoallylic alcohols. The cyclopropanation of allylic carbamates has also been investigated with this system, but it was found that enantioenriched cyclopropylmethylamines are best prepared from enantioenriched cyclopropylmethanols.
Charette, André B.,Juteau, Hélène,Lebel, Hélène,Molinaro, Carmela
p. 11943 - 11952
(2007/10/03)
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