- DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF
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The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.
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Paragraph 00071
(2020/07/14)
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- IRAK DEGRADERS AND USES THEREOF
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The present invention provides compounds, compositions thereof, and methods of using the same.
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Paragraph 3211; 3213
(2019/07/10)
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- PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE and INFLAMMATORY DISEASES
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The present invention relates to compounds that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation, and particular
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Page/Page column 39-40
(2009/07/17)
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- PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE and INFLAMMATORY DISEASES
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The present invention relates to compounds that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation, and particular
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Page/Page column 48-49
(2009/07/17)
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- AROMATIC COMPOUND
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An aromatic compound represented by the following formula or a pharmaceutically acceptable salt thereof: , wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., G1, G2, G3, G4 and G5 are CH or N, X is -NH-, -O-, -CH2-, etc., Y is - CH2-,-CO-,-SO2- etc., Z is a single bond, -CO-, -SO2-, -NH-, -O-, -S-, -CONH-,-SO2NH-, etc., R2 is hydrogen, alkyl, alkoxy, halogen, etc., and R3 is carbocyclic group, heterocyclic group, alkyl, etc., is useful as a controlling agent of the function of CCR4 useful for the treatment or therapy for bronchial asthma, atopic dermatitis, etc.
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Page/Page column 40
(2008/12/07)
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- ALICYCLIC HETEROCYCLIC COMPOUND
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An alicyclic heterocyclic compound represented by the following formula or a pharmaceutically acceptable salt thereof: wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., P1 and P2 are CH or N, q and r are 0 to 2, X is -NH-, -O-, -CH2-, etc., Y is -CH2-, -CO-, -SO2-, etc., Z is -CO-, -SO2-, etc., and R3 is carbocyclic group, heterocyclic group, hydroxyl, alkoxy or amino, is useful as a controlling agent of the function of CCR4 useful for the prevention or treatment for bronchial asthma, atopic dermatitis, etc.
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Page/Page column 91
(2008/12/08)
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- Novel compounds useful for the treatment of degenerative and inflammatory diseases
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The present invention relates to compounds that are inhibitors of PDE1A, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation.
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- SYNTHESES BASED ON DIMETHYLPYRAZOLES. VII. PYRAZOLE ANALOGS OF ANTHRANILIC ACID AND ITS AMIDE. DERIVATIVES OF N-PYRAZOLYLNAPHTHALIMIDES
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1-Methyl-4-nitropyrazole-5-carboxylic acid was obtained by the nitration of 1-methylpyrazole-5-carboxylic acid.It was used for the synthesis of 4-amino-1-methylpyrazole-5-carboxylic acid and its amide. 4-Amino-1-methyl-5-carbamoylpyrazole reacts with naphthalic anhydride in acetic acid only at 185-190 deg C with the formation of 1-methyl-1H-pyrazolopyrimidinobenzo-5,13-(5H,13H)isoquinolinedione.The reaction with 4-nitronaphthalic anhydride takes place in acetic acid on boiling.The obtained 2-(5-carbamoyl-1-methyl-4-pyrazolyl)-7-nitrobenzo-1,3-(1H,3H)isoquinolinedione was converted by dehydration in phosphorus oxychloride into the corresponding nitrile and nitrodione.The latter was reduced to the aminodione.The IR and electronic spectra of the dione and nitro- and aminodiones were studied.
- Perevalov, V. P.,Andreeva, M. A.,Manaev, Yu. A.,Isaev, Sh. G.,Baryshnenkova, L. I.,Stepanov, B. I.
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p. 976 - 980
(2007/10/02)
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