Alkyne Cycloadditions Mediated by Tetrabutylammonium Fluoride: A Unified and Diversifiable Route to Isoxazolines and Pyrazolines
A versatile approach to isoxazolines and pyrazolines by the cyclization of alkyne substrates using tetrabutylammonium fluoride (TBAF) is described. The reported diheteroatom cycles were produced under mild reaction conditions and with broad product scope.
On the viability of 5-endo-dig cyclisations of O-propargylic hydroxylamine derivatives, leading to 2,5-dihydroisoxazoles (3-isoxazolines)
O-Propargylic hydroxylamines undergo smooth 5-endo-dig cyclisations upon exposure to 3 equiv of molecular iodine to give respectable yields of the corresponding 4-iodo-2,5-dihydroisoxazoles, which should find a number of applications as intermediates for syntheses amongst this useful class of heterocycles.
Foot, Oliver F.,Knight, David W.,Low, Ai Cheng Lilian,Li, YingFa
p. 647 - 650
(2007/10/03)
More Articles about upstream products of 925428-18-8