- Regioselective three-component synthesis of 1,2-diarylindoles from cyclohexanones, α-hydroxyketones and anilines under transition-metal-free conditions
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A facile method for the one-pot synthesis of 1,2-diarylindoles under transition-metal-free conditions is described. Cyclohexanones were used as the aryl sources via the dehydrogenative aromatization process. One C-C and two C-N bonds were selectively formed via a domino reaction. This protocol provides a convenient approach for the construction of valuable bioactive 1,2-diarylindoles from readily available cyclohexanones, α-hydroxyketones and anilines.
- Li, Cheng,Xie, Yanjun,Xiao, Fuhong,Huang, Huawen,Deng, Guo-Jun
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supporting information
p. 4079 - 4082
(2019/04/25)
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- Novel α-tosyloxylation of ketones catalyzed by the in situ generated hypoiodous acid from alkyl iodide
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Using a catalytic amount of 1-iodopropane, a novel and efficient procedure has been developed for direct preparation of α-tosyloxyketones from ketones. In this protocol, 1-iodopropane is first oxidized into iodosylpropane, which decomposes to form the key
- Zhang, Bijun,Han, Liuquan,Hu, Jiantao,Yan, Jie
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p. 5851 - 5854
(2015/01/16)
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- Effective α-tosyloxylation of ketones using 1,1,1-trifluoro-2-iodoethane as catalyst
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With 1,1,1-trifluoro-2-iodoethane as catalyst, a novel and efficient procedure has been developed for preparation of α-tosyloxyketones from ketones. In this protocol, 1,1,1-trifluoro-2-iodoethane is first oxidized by m-chloroperbenzoic acid to a hypervale
- Zhang, Bijun,Han, Liuquan,Hu, Jiantao,Yan, Jie
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supporting information
p. 3264 - 3270
(2015/10/06)
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- A novel one-pot method for αα-tosyloxylation of ketones using a catalytic amount of ammonium iodide
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A novel one-pot procedure was designed for the preparation of various α-tosyloxy ketones in good yields by the reaction of ketones with m-chloroperoxybenzoic acid and p-toluenesulfonic acid monohydrate in the presence of catalytic amounts of ammonium iodi
- Hu, Jiantao,Zhu, Min,Xu, Yuan,Yan, Jie
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experimental part
p. 1226 - 1232
(2012/05/20)
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- Iodoarene-mediated α-tosyloxylation of ketones with MCPBA and p-toluenesulfonic acid
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Alkyl aryl ketones and dialkyl ketones could be converted into the corresponding α-tosyloxy ketones by the reaction with MCPBA and p-toluenesulfonic acid monohydrate (PTSA ? H2O) in the presence of a catalytic amount of molecular iodine (I
- Tanaka, Ayumi,Moriyama, Katsuhiko,Togo, Hideo
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experimental part
p. 1853 - 1858
(2011/09/16)
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- Catalytic, asymmetric, interrupted Feist-Benary reactions of α-tosyloxyacetophenones
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A new variant of the Interrupted Feist-Benary (IFB) reaction uses α-tosyloxyacetophenones as electrophiles and proceeds in good yields and excellent enantioselectivities.
- Calter, Michael A.,Korotkov, Alexander
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supporting information; experimental part
p. 6328 - 6330
(2012/01/11)
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- Novel preparation of polymer-supported iodobenzene and its synthetic utility as a recyclable reagent with m-chloroperbenzoic acid
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Three novel polymer-supported iodobenzene compounds A0, A 6, and A10 were prepared from the reaction of commercially available cross-linked poly(p-chloromethyl)styrene with m-iodobenzylalcohol, 6-(m-iodobenzyloxy)-1-hexanol, and 10-(m-iodobenzyloxy)-1-decanol. Their catalytic reactivity and reusability for the oxidative α-tosyloxylation of ketones and the cyclization of N-methoxy-2-arylethanesulfonamides in the presence of m-chloroperbenzoic acid (mCPBA) were confirmed to provide -tosyloxyketones and N-methoxy-3,4-dihydro-2,1-benzothiazine-2,2-dioxides, respectively, in good yields. Georg Thieme Verlag Stuttgart · New York.
- Suzuki, Yuhsuku,Togo, Hideo
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experimental part
p. 2355 - 2360
(2010/09/18)
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- α-Tosyloxylation of ketones with ion-supported[hydroxy(tosyloxy)iodo] benzene
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A new room-temperature ionic liquid (RTIL) supported [hydroxy(tosyloxy) iodo]benzene (ion-supported HTIB) reagent was synthesised by three kinds of effective methods in high yields, which combined the advantages of ionic liquids and the hypervalent iodine
- Su, Feng,Zhang, Jizhen,Jin, Guangyu,Qiu, Tao,Zhao, Dejian,Jia, Hongbin
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experimental part
p. 741 - 744
(2010/03/24)
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- 4-MeC6H4I-mediated efficient -tosyloxylation of ketones with oxone and p- toluenesulfonic acid in acetonitrile
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Various alkyl aryl ketones, dialkyl ketones, and cycloheptanone were efficiently converted into the corresponding -tosyl-oxy ketones in good yields by using Oxone and p-toluenesulfonic acid monohydrate in the presence of p-iodotoluene in aceton
- Tanaka, Ayumi,Togo, Hideo
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experimental part
p. 3360 - 3364
(2010/03/03)
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- Convenient synthesis of symmetrical diketosulfides from enolizable ketones using [hydroxy(tosyloxy)iodo]benzene and Na2S·9H20
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An efficient method for the preparation of symmetrical diketosulfides of the type ArCOCH2SCH2COAr has been developed from the reaction of [hydroxy(tosyloxy)iodo]benzene with various acetophenones, followed by treatment with Na2
- Karade, Nandkishor N.,Tiwari, Girdharilal B.,Gampawar, Sumit V.,Shinde, Sandeep V.
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experimental part
p. 172 - 176
(2009/09/30)
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- Hypervalent iodine in the synthesis of bridgehead heterocycles: A facile route to the synthesis of 6-arylimidazo[2,1-b]thiazoles using [hydroxy(tosyloxy)iodo]benzene
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α-Tosyloxyketones (2), readily accessible through hypervalent iodine oxidation of enolizable ketones (1) using [hydroxy(tosyloxy)iodo]benzene (HTIB) in acetonitrile, exclusively generates the 6-arylimidazo[2,1-b]thiazoles (4) on treatment with commerciall
- Aggarwal, Ranjana,Sumran, Garima
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p. 875 - 879
(2007/10/03)
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- A facile [hydroxy(tosyloxy)iodo]benzene mediated synthesis of 2-arylimidazo[1,2-a]pyrimidines and their conversion into 3-bromo-2- arylimidazo[1,2-a]pyrimidines
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α-Tosyloxyketone 2, obtained through hypervalent iodine oxidation of enolizable ketones using [hydroxy(tosyloxy)iodo]benzene (HTIB) in acetonitrile, on treatment with 2-aminopyrimidine 3 generates regioselectively 2-arylimidazo[1,2-a]pyrimidine 6 which up
- Aggarwal, Ranjana,Sumran, Garima
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p. 2690 - 2695
(2007/10/03)
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