926020-85-1

Basic information

• Product Name: 4-[(2-chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
• Synonyms: 4-[(2-chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
• CAS NO: 926020-85-1
• Molecular Formula: C18H16ClN3O
• Molecular Weight: 325.79214
• Mol File: 926020-85-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(2-chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2-chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one(926020-85-1)
• EPA Substance Registry System: 4-[(2-chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one(926020-85-1)

Safety Data

• Hazardous Substances Data: 926020-85-1(Hazardous Substances Data)

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 89-98-5 2-chloro-benzaldehyde 

Relevant articles and documents

4-(4-Chlorobenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one and 4-(2-chlorobenzylideneamino)-1,5-dimethyl-2-phenyl-1 H-pyrazol-3(2H)-one

The two title compounds, both with formula C18H 16ClN3O, are structurally similar Schiff bases derived from the condensation of 4-chlorobenzaldehyde or 2-chlorobenzaldehyde with 4-aminoantipyrine in methanol solution. As e

Spectroscopic, electrochemical DNA binding and in vivo anti-inflammatory studies on newly synthesized Schiff bases of 4-aminophenazone

4-Aminophenazone (Ap-1) Schiff bases i.e., 4-{(3,4,5-trimethoxybenzylidine) amino}phenazone (Ap-2), 4-{(2-chlorobenzylidine) amino}phenazone (Ap-3) and 4-{(4-chlorobenzylidine)amino} phenazone (Ap-4) were synthesized and characterized by different spectro

Activated fly ash catalyzing the synthesis of novel potent 4-thiazolidinones of 4-amino antipyrine anils using CEM discover microwave methodology and their virtual screening

Fly ash, an industrial waste, has been used as an efficient and cost-effective activating catalyst for the synthesis of new potent thiazolidinones (4a-n), starting from imine (3a-n) and thioacetic acid. The reactions were performed under CEM Discover micr

Predictions and correlations of structure activity relationship of some aminoantipyrine derivatives on the basis of theoretical and experimental ground

A series of 4-aminoantipyrine derivatives were produced by condensing aromatic primary amine, namely, 4-aminoantipyrine with different aryl carbonyls which occurred cleanly and efficiently without using any catalyst at room temperature. Their structures w

Design, synthesis, antimicrobial, anticancer evaluation, and QSAR studies of 4-(substituted benzylidene-Amino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3- ones

A series of 4-(substituted benzylidene-Amino)-1,5-dimethyl-2-phenyl-1,2- dihydropyrazol-3-ones (1-17) was synthesized and tested in vitro for its antimicrobial and anticancer potentials. The biological screening results indicated that compounds having m-c

Synthesis and anti-bacterial activities of some novel schiff bases derived from aminophenazone

A series of 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one-containing Schiff bases were synthesized, characterized and screened for their antibacterial activities. The structures of the synthesized compounds were established by spectroscopic (FT-IR,

Synthesis and study of antibacterial activity of some Schiff bases derived from sulfonamide, 4-amino antipyrene and raceacetophenone

Schiff bases derived from sulfonamide, 4-amino antipyrene and raceacetophenone were screened for antibacterial activity against various clinical isolates (obtained from Urine, Blood, Tracheal secretion and Pus). Extracts of these compounds were evaluated on 5 pathogenic strains [E. coli, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumoniae and Staphylococcus aureus]. The antibacterial activity was evaluated using the Agar Ditch method. The Schiff bases produced were (1) 4-[2-aza-2- (2-chlorophenyl) vinyl] benzene sulfonamide [AD1] (2) 4-[2-aza-2- (2-hydroxyphenyl) vinyl] benzene sulfonamide [AD2] (3) [1-aza-4-phenylbuta-1, 3-dienyl] benzene sulfonamide [AD3] (4) 4-[1-aza-2- (2chlorophenyl) vinyl]-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one [AS1] (5) 4-[1-aza-2-(2-hydroxyphenyl) vinyl]-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one [AS2] (6) 4-[1-aza-4-phenylbuta-1, 3-dienyl] 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one [AS3] (7) 4-[2-aza-1-methyl-2- (2-nitro phenyl) vinyl]-6-ethylbenzene-1, 3-diol [ADS1] (8) 4-[2-aza-2(5-ehtyl-2, 4-dihydroxyphenyl) prop-1-enyl] benzene sulfonamide [ADS2]. The anti bacterial activity of these Schiff bases, were evaluated in one polar and one non polar (i.e., DMF and 1,4 dioxan) solvents. It is found that among AD and AS compounds AD compounds are better than AS and AD3 is the best while 1,4 dioxan solvent proved to be more effective than DMF. It appears that the sulfonamide moiety present with cinnamaldehyde side chain could be used as a lead molecule in drug designing (i.e. in inhibiting the above pathogenic bacteria).

Synthesis and antimicrobial activity of some 4-thiazolidinones

4-Thiazolidinones have been prepared by the reaction of mercaptoacetic acids with anils or with aldehydes and amines.The structures of some of the 4-thiazolidinones (III-V) have been established on the basis of their elemental analyses and spectral data.T

Synthesis and pharmacological screening of a new series of 3-(4-antipyryl)-2-arylthiazolidin-4-ones

A series of 3-(4-antipyryl)-2-arylthiazolidin-4-one derivatives were synthesized and pharmacologically evaluated for antinociceptive, spasmolytic and cardiovascular activities.The presence of a methoxy-naphthyl or a substituted phenyl group in 2-position