926275-68-5Relevant articles and documents
Method for preparing ropivacaine hydrochloride
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Paragraph 0028; 0058-0060; 0071-0073, (2021/12/07)
The preparation method comprises the following specific steps: 1) reacting (S)- piperidine -2 - formic acid with propionaldehyde in the presence of a reducing agent and an aprotic solvent to obtain the intermediate 1. 2). N. NIn the presence of -dimethylformamide and an aprotic solvent, the intermediate 1 obtained in step 1) and the acylating agent are subjected to an acylation reaction to give an intermediate 2. 3). N. N[-] The intermediate 2 obtained in step 2) and 2 and 6 -dimethylaniline are subjected to a condensation reaction in the presence of dimethylformamide and basic conditions to give an intermediate 3. 4) The intermediate 3 obtained in step 3) is salified with hydrochloric acid to give the ropivacaine hydrochloride crude product. 5) The ropivacaine hydrochloride is purified to obtain ropivacaine hydrochloride. The method has the advantages that the product purity is higher than 99.99%, the synthesis process is mild in reaction condition, simple in preparation process, low in cost, safe and environment-friendly, and is suitable for industrial production.
Thiophene derivatives of the new solid form and its preparation method and use thereof
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Paragraph 0065; 0071; 0072; 0073; 0074, (2018/07/30)
The invention relates to thiophene derivatives of the new solid form and its preparation method and use, the thiophene derivatives of the new solid state forms is compound 1 crystalline form I, compound 1 crystalline form II, compound 2 crystalline form I, compound 2 crystalline form II, the invention also relates to containing thiophene derivatives of the new solid form pharmaceutical composition and can be used for the local anesthetic and/or analgesic drug in the field of application. The present invention provides powder X - with obvious-ray diffraction Atlas characteristics of the new solid form, its preparation method is simple, it is convenient to store, is suitable for preparing a plurality of preparations,
Heterocyclic acylamide derivative and preparation method and pharmaceutical application thereof
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Paragraph 0177; 0183; 0184; 0185; 0186; 0187, (2017/07/19)
The invention relates to a heterocyclic acylamide derivative and a preparation method and pharmaceutical application thereof, in particular to a heterocyclic acylamide derivative shown as a general formula (I) or a stereoisomer and a pharmaceutically-acce
Amide derivative, preparation method of amide derivative, and application of amide derivative to pharmacy
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Paragraph 0338; 0339; 0040; 0041; 0042; 0043; 0468, (2017/08/30)
The invention provides an amide derivative, a preparation method of the amide derivative, and application of the amide derivative to pharmacy. The amide derivative compound is selected from one of the following structures. The compound can be used for preparing medicines in the fields of local anaesthesia or analgesia. (The formulas are as shown in the description).
Substituted piperidine amide derivative, preparation method thereof, and application of derivative to pharmacy
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Paragraph 0557; 0558, (2017/08/30)
The invention relates to a substituted piperidine amide derivative as shown in a general formula (I) or a stereisomer and pharmaceutically acceptable salt thereof, a preparation method of the derivative, medicinal combination as well as application of the derivative to the aspects of local anaesthesia or analgesia. The definition of each group of the general formula (I) is consistent with that of the description. (The general formula (I) is as shown in the description).
