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4-[4-[(2-Bromophenyl)methyl]-1-piperazinyl]benzoic Acid Ethyl Ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

926934-01-2

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926934-01-2 Usage

Chemical Properties

Light Brown Solid

Check Digit Verification of cas no

The CAS Registry Mumber 926934-01-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,6,9,3 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 926934-01:
(8*9)+(7*2)+(6*6)+(5*9)+(4*3)+(3*4)+(2*0)+(1*1)=192
192 % 10 = 2
So 926934-01-2 is a valid CAS Registry Number.

926934-01-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 4-[4-[(2-bromophenyl)methyl]piperazin-1-yl]benzoate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:926934-01-2 SDS

926934-01-2Relevant articles and documents

INHIBITING B-CELL LYMPHOMA 2 (BCL-2) AND RELATED PROTEINS

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Paragraph 00144, (2017/09/05)

Novel compounds inhibiting anti-apoptosis proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL include compounds of formula (I) and formula (II) disclosed herein, as well as liposome compositions comprising Bcl-2 inhibitor compounds. These compositions are usefu

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

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Page/Page column 43, (2010/08/07)

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

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Page/Page column 48, (2010/08/07)

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

BCL-2 INHIBITORS CONTAINING A ZINC BINDING MOIETY

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Page/Page column 51, (2009/04/25)

The present invention relates to Bcl-2 inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The compounds of the invention may further act as HDAC inhibitors

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

Bruncko, Milan,Oost, Thorsten K.,Belli, Barbara A.,Ding, Hong,Joseph, Mary K.,Kunzer, Aaron,Martineau, Darlene,McClellan, William J.,Mitten, Michael,Ng, Shi-Chung,Nimmer, Paul M.,Oltersdorf, Tilman,Park, Cheol-Min,Petros, Andrew M.,Shoemaker, Alexander R.,Song, Xiaohong,Wang, Xilu,Wendt, Michael D.,Zhang, Haichao,Fesik, Stephen W.,Rosenberg, Saul H.,Elmore, Steven W.

, p. 641 - 662 (2007/10/03)

Overexpression of the antiapototic proteins Bcl-2 and Bcl-xL provides a common mechanism through which cancer cells gain a survival advantage and become resistant to conventional chemotherapy. Inhibition of these prosurvival proteins is an attractive strategy for cancer therapy. We recently described the discovery of a selective Bcl-xL antagonist that potentiates the antitumor activity of chemotherapy and radiation. Here we describe the use of structure-guided design to exploit a deep hydrophobic binding pocket on the surface of these proteins to develop the first dual, subnanomolar inhibitors of Bcl-xL and Bcl-2. This study culminated in the identification of 2, which exhibited EC50 values of 8 nM and 30 nM in Bcl-2 and Bcl-xL dependent cells, respectively. Compound 2 demonstrated single agent efficacy against human follicular lymphoma cell lines that overexpress Bcl-2, and efficacy in a murine xenograft model of lymphoma when given both as a single agent and in combination with etoposide.

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