Design-driven LO: The discovery of new ultra long acting dibasic β2-adrenoceptor agonists
Starting with the molecular scaffold of the DA2/β 2 dual agonist sibenadet (Viozan), a number of molecular changes were incorporated, which were designed to increase the potency and selectivity of the target molecule, and improve its
Connolly, Stephen,Alcaraz, Lilian,Bailey, Andrew,Cadogan, Elaine,Christie, Jadeen,Cook, Anthony R.,Fisher, Adrian J.,Hill, Stephen,Humphries, Alexander,Ingall, Anthony H.,Kane, Zoe,Paine, Stuart,Pairaudeau, Garry,Stocks, Michael J.,Young, Alan
p. 4612 - 4616
(2011/09/12)
7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS
The present invention provides compounds of formula (I) wherein the variables are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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(2008/06/13)
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