- SUBSTITUTED AZAHETEROCYCLES FOR THE TREATMENT OF CANCER
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The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
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Page/Page column 26; 32
(2013/03/26)
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- Amide-based inhibitors of p38α MAP kinase. Part 2: Design, synthesis and SAR of potent N-pyrimidyl amides
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Optimization of a tri-substituted N-pyridyl amide led to the discovery of a new class of potent N-pyrimidyl amide based p38α MAP kinase inhibitors. Initial SAR studies led to the identification of 5-dihydrofuran as an optimal hydrophobic group. Additional
- Tester, Richland,Tan, Xuefei,Luedtke, Gregory R.,Nashashibi, Imad,Schinzel, Kurt,Liang, Weiling,Jung, Joon,Dugar, Sundeep,Liclican, Albert,Tabora, Jocelyn,Levy, Daniel E.,Do, Steven
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scheme or table
p. 2560 - 2563
(2010/07/03)
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- 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
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The present invention provides 6-substituted 2,3,4,5-tetrahydro-lH- benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety, where, R6 is -NR10R11, where R10 is substituted phenylalkyl or substituted pyridylalkyl and other substituents are as defined in the specification.
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Page/Page column 148
(2010/11/26)
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