92886-86-7Relevant articles and documents
Catalytic diastereoselective polycyclization of homo(polyprenyl)arene analogues bearing terminal siloxyvinyl groups
Uyanik, Muhammet,Ishihara, Kazuaki,Yamamoto, Hisashi
, p. 5649 - 5652 (2007/10/03)
Highly diastereoselective polycyclization of homo(polyprenyl)arene analogues bearing terminal siloxyvinyl groups was catalyzed by tin(IV) chloride (10 mol %). The cyclizations of tert-butyldiphenylsilyl and triisopropylsilyl polyenol ethers gave 4α(equatorial)- and 4β(axial)-siloxypolycycles as major isomers, respectively. The strong nucleophilicity of pro-C(9), a (6E) geometry, and a bulky silyl group effectively favored the 4α-preference, whereas the weak nucleophilicity of pro-C(9), a (6Z)-geometry, and less steric hindrance of a silyl group favored the 4β-preference.
Mechanistic studies on the O-directed free-radical hydrostannation of disubstituted acetylenes with Ph3SnH and Et3B and on the lodination of allylically oxygenated α-triphenylstannylalkenes
Dimopoulos, Paschalis,George, Jonathan,Tocher, Derek A.,Manaviazar, Soraya,Hale, Karl J.
, p. 5377 - 5380 (2007/10/03)
(Chemical Equation Presented) The free-radical hydrostannation of 1 with Ph3SnH and catalytic Et3B in PhMe has been mechanistically probed. At high Ph3SnH concentrations, the O-directed hydrostannation pathway dominates, a
Stereocontrolled synthesis of the ABCDE ring moiety of ciguatoxin CTX3C
Kobayashi, Shoji,Takahashi, Yusuke,Komano, Kazuo,Alizadeh, Babak H.,Kawada, Yuuya,Oishi, Tohru,Tanaka, Shin-Ichiro,Ogasawara, Yoshihiro,Sasaki, Shin-Ya,Hirama, Masahiro
, p. 8375 - 8396 (2007/10/03)
The ABCDE ring moiety of ciguatoxin CTX3C, a major causative agent of ciguatera poisoning, was stereoselectively synthesized. The key transformations are a chiral auxiliary-based asymmetric alkylation and an asymmetric aldol condensation, which controlled
Process for producing novel naphthyridine derivatives
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, (2008/06/13)
A novel naphthyridine derivative showing high activity as a tachykinin receptor antagonist can be produced at high efficiency by reacting an acylating agent such as a carboxylic acid derivative with a compound represented by the formula (1): wherein R1, R2 and R3 represent independently a hydrogen atom, a lower alkyl group, a lower alkoxyl group, an aryl group, a heteroaryl group, an amino group, etc., and X1 and X2 represent respectively a halogen atom.
An alternative synthesis of (+)-sesbanimide A
Vloon, W. J.,Bos, J. C. van den,Willard, N. P.,Koomen, G.-J.,Pandit, U. K.
, p. 414 - 419 (2007/10/02)
D-(+)-xylose has been converted to (+)-sesbanimide A in sixteen steps.The synthetic scheme involves an ususual tricyclic silylated derivative (9a) of the monobenzoylated product of the earlier described glutarimide intermediate (7).Compound 9a is a pivotal intermediate for the construction of ring C of (+)-sesbanimide A.
THE SYNTHESIS OF FUNCTIONALISED SILYLTRIFLATES
Bassindale, Alan R.,Stout, Tim
, p. C1 - C3 (2007/10/02)
The cleavage of R2SiXY (R = alkyl, phenyl; X = H, Cl, Y = α-Np, Ph, Cl, H) by triflic acid is selective, leading to new difunctional silyltriflates, R2SiXOTf, with the relative ease of cleavage of Si-Y being, α-Np > Ph > Cl > H >> Me, Et, But.
