Molecular-docking-guided design, synthesis, and biologic evaluation of radioiodinated quinazolinone prodrugs
Enzyme-mediated cancer imaging and therapy (EMCIT) is a novel approach in which radioactive water-soluble molecules are precipitated in vivo following their hydrolysis by extracellular enzymes overexpressed by cancer cells. AutoDock 3.0 was used to model
Chen, Kai,Al Aowad, Ayman F.,Adelstein, S. James,Kassis, Amin I.