930395-74-7Relevant articles and documents
Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5negative allosteric modulation
Gómez-Santacana, Xavier,Dalton, James A.R.,Rovira, Xavier,Pin, Jean Philippe,Goudet, Cyril,Gorostiza, Pau,Giraldo, Jesús,Llebaria, Amadeu
, p. 567 - 576 (2017/01/28)
Modulation of metabotropic glutamate receptor 5 (mGlu5) with partial allosteric antagonists has received increased interest due to their favourable in?vivo activity profiles compared to the unfavourable side-effects of full inverse agonists. He
Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2- ethanediones: Potent, selective carboxylesterase inhibitors
Young, Brandon M.,Hyatt, Janice L.,Bouck, David C.,Chen, Taosheng,Hanumesh, Parimala,Price, Jeanine,Boyd, Vincent A.,Potter, Philip M.,Webb, Thomas R.
supporting information; experimental part, p. 8709 - 8715 (2011/02/23)
Inhibition of intestinal carboxylesterases may allow modification of the pharmacokinetics/pharmacodynamic profile of existing drugs by altering half-life or toxicity. Since previously identified diarylethane-1,2-dione inhibitors are decidedly hydrophobic,