931717-78-1

Basic information

• Product Name: 8-hydroxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin
• Synonyms: 8-hydroxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin
• CAS NO: 931717-78-1
• Molecular Weight: 320.304
• Mol File: 931717-78-1.mol

Chemical Properties

• CAS DataBase Reference: 8-hydroxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 8-hydroxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin(931717-78-1)
• EPA Substance Registry System: 8-hydroxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin(931717-78-1)

Safety Data

• Hazardous Substances Data: 931717-78-1(Hazardous Substances Data)

Upstream product

• 19227-13-5 p-toluamidoxime 
• 58599-00-1 5-cyanomethyl-3-(4-methylphenyl)-1,2,4-oxadiazole 
• 24677-78-9 2,3-dihydroxybenzaldehyde 

Downstream Products

• 1260708-18-6 8-(2-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin 
• 1260743-79-0 8-(4-fluorobenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin 
• 1401254-89-4 8-(3-methylbenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin 
• 1260730-35-5 8-(4-methylbenzyl)oxy-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]coumarin 

Relevant articles and documents

Isomeric 3-isoxadiazolylcoumarins and their derivatives

Here, we represent preparative methods of synthesis of isomeric 3-isoxadiazolylcoumarins and their derivatives. Two new synthetic methods have been developed for 3-[1,2,4-oxadiazol-5-yl]coumarins I. The first method is based on a three-component condensation of coumarin-;3-carboxylic acids, 1,1'-carbonyldiimidazole, and amidoximes. The second method essentially uses the interaction of 5-cyanomethyl-1,2,4-oxadiazoles with salicylic aldehydes. General approach for preparation of 3-[1,2,4-oxadiazol-3-yl]coumarins II has been worked out. Moreover, aforementioned synthetic ways open the way for the synthesis of 2-iminoderivatives III and IV not described before, those were diversified by reaction of nucleophilic substitution of 2-imino group with a numerous amino compounds.