ON THE PHOSPHORYLATION OF DEOXYRIBONUCLEOSIDES AND THE PROTECTION OF DEOXYGUANOSINE
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Francois, P.,Hamoir, G.,Sonveaux, E.,Vermeersch, H.,Ma, Y.
p. 821 - 824
(2007/10/02)
Improved Synthesis of Oligodeoxyribonucleotides by Solid-Phase Phosphotriester Method Utilizing O6--2'-deoxyguanosine Derivatives
The synthesis of oligodeoxyribonucleotides on a cross-linked polystyrene solid support utilizing stable mono- and dinucleotide phosphotriester building blocks is presented.The use of O6--2'deoxyguanosine derivatives yields cleaner DNA fragments by supressing side reactions.Modifications improving the phosphotriester methodology are presented.The purification methods and analysis of synthetic oligodeoxyribonucleotides are described.
Chollet, Andre,Ayala, Edgar,Kawashima, Eric H.
p. 1356 - 1364
(2007/10/02)
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