Operationally convenient asymmetric synthesis of (S)- and (R)-3-amino-4,4,4-trifluorobutanoic acid. Part I: Enantioselective biomimetic transamination of isopropyl 4,4,4-trifluoro-3-oxo-butanoate
DBU-catalyzed asymmetric synthesis of (S)- and (R)-3-amino-4,4,4-trifluorobutanoic acid via enantioselective biomimetic transamination of isopropyl 4,4,4-trifluoro-3-oxobutanoate with (R)- and (S)-phenylethylamine has been developed. The effect of the bas