2′-O-hydroxyalkoxymethylribonucleosides and their incorporation into oligoribonucleotides
A simple and efficient method for the preparation of pyrimidine 2′-O-hydroxyethoxymethylribonucleosides and 2′-O- hydroxypropoxymethylribonucleosides has been developed. These modified nucleosides were incorporated into oligoribonucleotides, which were sh
Mikhailov, Sergey N.,Bobkov, Georgii V.,Brilliantov, Kyrill V.,Rozenski, Jef,Van Aerschot, Arthur,Herdewijn, Piet,Fisher, Michael H.,Juliano, Rudolph L.
Synthesis of oligoribonucleotides containing pyrimidine 2′-O-[(hydroxyalkoxy)methyl]ribonucleosides
A simple and efficient method for the preparation of pyrimidine 2′-O-[(2-hydroxyethoxy)methyl]ribonucleosides and 2′-O-[(3- hydroxypropoxy)methyl]ribonucleosides has been developed. These modified nucleosides were incorporated into oligoribonucleotides, which were shown to form stable RNA/RNA duplexes.