Design, chemical synthesis of 3-(9H-fluoren-9-yl)pyrrolidine-2,5-dione derivatives and biological activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis
We report here the discovery, synthesis and screening results of a series of 3-(9H-fluoren-9-yl)pyrrolidine-2,5-dione derivatives as a novel class of potent inhibitors of Mycobacterium tuberculosis H37Rv strain as well as the enoyl acyl carrier protein re
Matviiuk, Tetiana,Rodriguez, Frédéric,Saffon, Nathalie,Mallet-Ladeira, Sonia,Gorichko, Marian,De Jesus Lopes Ribeiro, Ana Luisa,Pasca, Maria Rosalia,Lherbet, Christian,Voitenko, Zoia,Baltas, Michel