- Analgesic, anti-inflammatory activity and docking study of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4-ones
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A potential analgesic and anti-inflammatory activities have been reported in 4-thiazolidinone analogs as well as some drugs bearing naphthyl moiety such as naproxen. Thus a reported series of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4-ones (T
- Agrawal, Neetu,Upadhyay, Prabhat K.,Mujwar, Somdutt,Mishra, Pradeep
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- Analgesic, anti-inflammatory activity and docking study of 2-(substituted phenyl)-3-(naphthalen- 1-yl)thiazolidin-4-ones
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A potential analgesic and anti-inflammatory activities have been reported in 4-thiazolidinone analogs as well as some drugs bearing naphthyl moiety such as naproxen. Thus a reported series of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4- ones (
- Agrawal, Neetu,Upadhyay, Prabhat K.,Mujwar, Somdutt,Mishra, Pradeep
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- Synthesis, characterization, and antiproliferative and apoptosis inducing effects of novel: S -triazine derivatives
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In an attempt to design and synthesize a new class of antitumor agents, a mild and eco-friendly protocol for nucleophilic substitution using an s-triazine scaffold, via amine and Schiff base derivatives, has been developed. In order to obtain antitumor activity, all synthesized compounds were screened in vitro for their cytotoxicity against human fibrosarcoma tumor cells (HT-1080) and a cervical cancer cell line (HeLa), for their ability to inhibit the growth of cancer cells. The selected s-triazine analogs (5c, 5d, and 6c) have been preliminarily studied for their reactive oxygen species (ROS) properties, mitochondrial membrane potential (MMP) and apoptosis (AO/EtBr) activity against the HT-1080 cancer cell line. The in vitro anticancer activity analysis has revealed that the synthesized compounds have good/moderate inhibitory activity against the tested cell lines compared to the standard drug. The theoretical study results also provide evidence that the s-triazines scaffolds have been successfully identified as superior p53-MDM2 inhibitors through structure-based design.
- Shanmugam, Mani,Narayanan, Kuppusamy,Hari Prasad, Kamatam,Karthikeyan, Dhanapalan,Chandrasekaran, Loganathan,Atchudan, Raji,Chidambaranathan
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p. 1698 - 1714
(2018/02/09)
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- Synthesis and antimicrobial evaluation of some 4-thiazolidinone derivatives containing polynuclear hydrocarbon
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Some 4-thiazolidinone derivatives have also been known to be associated with several biological activities thus can be utilized as promising scaffold for developing analogues. Aryl aldehydes were treated with naphthylamine to yield corresponding Schiff's
- Verma, Neelam,Singh, Raj Bhushan,Singh, Kuldeep
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p. 2521 - 2523
(2016/10/12)
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- A thermal study of some Schiff bases derivative of α-napthylamine
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Thermal analyses of some Schiff bases, derivative of α-napthylamine, were performed by the DSC, TG and DTA techniques. The thermograms were used to determine various kinetic parameters, such as the order of degradation (n), energy of activation (E), frequ
- Baluja, Shipra,Pandya, Nirmal,Vekariya, Nayan
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experimental part
p. 1601 - 1604
(2009/02/03)
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- A study of anti-inflammatory activity of some novel α-amino naphthalene and β-amino naphthalene derivatives
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In the present study, some naphthalene derivatives have been synthesized by incorporating azetidinyl and thiazolidinyl moieties at its α- or β-positions such as a-(3-chloro-2-oxo-4-substitute-d)aryl-1-azetidinyl) naphthalenes 6-10, α-((substituted)aryl-4-
- Sharma, Shalabh,Singh, Tripti,Mittal, Rajan,Saxena,Srivastava, Virendra Kishore,Kumar, Ashok
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p. 145 - 152
(2007/10/03)
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- Scandium(III) catalysis of transimination reactions. Independent and constitutionally coupled reversible processes
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Sc(OTf)3 efficiently catalyzes the self-sufficient transimination reaction between various types of C=N bonds in organic solvents, with turnover frequencies up to 3600 h-1 and rate accelerations up to 6 × 105. The mechanism of the crossover reaction in mixtures of amines and imines is studied, comparing parallel individual reactions with coupled equilibria. The intrinsic kinetic parameters for isolated reactions cannot simply be added up when several components are mixed, and the behavior of the system agrees with the presence of a unique mediator that constitutes the core of a network of competing reactions. In mixed systems, every single amine or imine competes for the same central hub, in accordance with their binding affinity for the catalyst metal ion center. More generally, the study extends the basic principles of constitutional dynamic chemistry to interconnected chemical transformations and provides a step toward dynamic systems of increasing complexity.
- Giuseppone, Nicolas,Schmitt, Jean-Louis,Schwartz, Evan,Lehn, Jean-Marie
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p. 5528 - 5539
(2007/10/03)
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- Preparation and characterization of chromophor group containing cyclotriphosphazenes: I imino chromophor carrying some cyclotriphosphazenes
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Some new substituted cyclotriphosphazenes were prepared by the reaction of hexachlorocyclotriphophazene and 4-hydroxy or 4′-hydroxy Schiff bases as 4′-hydroxybenzylideneaniline, 4′-hydroxy-4-chlorobenzylideneaniline, 4′-hydroxy-2-chlorobenzylidenaniline, 4′-hydroxyfurfurylidenaniline, 4-hydroxybenzylidene-2′-methylaniline, 4-hydroxybenzylidene-2′,6′-dimethylaniline, 4-hydroxybenzylidene-2′-chloroaniline, 4-hydroxybenzylidene-4′-tert-butylaniline, 4′-hydroxybenzylidene-3,4-15-Crown-5-aniline. The structure of compounds with a general formula [NP(OC6H4CH=N-Ar)2]3, or [NP(OC6H4N=CH-Ar)2]3, was determined by IR, UV, 1H-NMR and elemental analysis. IR spectra of all compounds showed four characteristic bands located at 1633-1601cm-1, 1242-1150cm-1, 1278-1261cm-1 and 958-943cm-1, respectively, corresponding to CH=N, P=N, P-N-P (asymmetric) and P-N-P (symmetric) vibrations. Charasterictic UV bands, named as Band I, Band II, Band III and Band IV located at 346-308nm, 294-271nm, 262-216nm and 240-210nm respectively, are due to electronic transitions. The 1H-NMR spectra of 4-hydroxyfurfurylidene and the phosphazene derivative shows cis-trans izomerization below 305°K and 295°K.
- Odabasoglu, Mustafa,Turgut, Guenseli,Karaer, Hatice
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- Quantitative solid-solid synthesis of azomethines
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Twenty preparatively useful azomethines have been quantitatively (100% yield at 100% conversion) obtained as hydrates by grinding together solid anilines with solid benzaldehydes without passing through liquid phases. Unlike (acid catalyzed) azomethine syntheses in solution, the solid-solid condensations proceed 'waste-free'. The solid-state mechanisms have been elucidated by atomic force microscopy (AFM) and in part by scanning near-field optical microscopy (SNOM) in three cases. The results indicate long distance migration of the aldehydes into the lattice of the aniline derivatives. Stumpy protrusions are formed at the direct points of contact but also distance sublimation (100 nm range) is succesful in the case of p-chlorobenzaldehyde and p-nitroaniline. Long-range flow of 4-hydroxybenzaldehyde molecules on its (010)-face into contracting crystals of p-toluidine or p-anisidine occurs along two different cleavage planes. Steep hills and valleys are left behind. The molecular migrations through the sites of contact are interpreted in terms of crystals packing. The ease of these solid-solid condensation reactions relies on the crystal packing.
- Schmeyers, Jens,Toda, Fumio,Boy, Juergen,Kaupp, Gerd
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p. 989 - 993
(2007/10/03)
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