Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX)
Autotaxin (ATX) is a secreted soluble enzyme that generates lysophosphatidic acid (LPA) through its lysophospholipase D activity. Because of LPA's role in neoplastic diseases, ATX is an attractive therapeutic target due to its involvement in LPA biosynthe
East, James E.,Kennedy, Andrew J.,Tomsig, Jose L.,De Leon, Alexandra R.,Lynch, Kevin R.,MacDonald, Timothy L.
supporting information; experimental part
p. 7132 - 7136
(2010/12/25)
Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors
Autotaxin (ATX) is an autocrine motility factor that promotes cancer cell invasion, cell migration, and angiogenesis. ATX, originally discovered as a nucleotide phosphodiesterase, is known now to be responsible for the lysophospholipid-preferring phosphol
Cui, Peng,Tomsig, Jose L.,McCalmont, William F.,Lee, Sangderk,Becker, Christopher J.,Lynch, Kevin R.,Macdonald, Timothy L.
p. 1634 - 1640
(2007/10/03)
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