- MORPHOLINE CARBOXAMIDE PROKINETICIN RECEPTOR ANTAGONISTS
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The present invention is directed to morpholine carboxamide compounds which are antagonists of prokineticin receptors, in particular antagonists of prokineticin 2 receptors, and which are useful in the treatment or prevention of neurological and psychiatr
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Page/Page column 40
(2008/06/13)
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- Anilide derivative, production and use thereof
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This invention is to provide a compound of the formula: wherein R1is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula: ?wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5and R6are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R5and R6may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a salt thereof , which is useful for antagonizing CCR5 and also for the prevention and treatment of infectious disease of HIV.
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- ACETYLATION, BROMINATION, AND NITRATION OF BENZOXAHETEROCYCLES AND SYNTHESIS OF β-AMINOKETONES FROM ACETYL DERIVATIVES
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The method of competing reactions was used to establish the sequence of variation of the relative rates of acetylation, bromination, and nitration reactions of 2-methylcoumaran, chroman, 2,3,4,5-tetrahydrobenzo-1-oxepan, and 1-methoxy-2-ethylbenzene.The i
- Daukshas, V. K.,Pyatrauskas, O. Yu.,Udrenaite, E. B.,Gaidyalis, P. G.,Gasperavichene, G. A.
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p. 838 - 841
(2007/10/02)
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