Asymmetric Transfer Hydrogenation of Unhindered and Non-Electron-Rich 1-Aryl Dihydroisoquinolines with High Enantioselectivity
The use of arene/Ru/TsDPEN catalysts bearing a heterocyclic group on the TsDPEN in the asymmetric transfer hydrogenation (ATH) of dihydroisoquinolines (DHIQs) containing meta- or para-substituted aromatic groups at the 1-position results in the formation of products of high enantiomeric excess. Previously, only 1-(ortho-substituted)aryl DHIQs, or with an electron-rich fused ring gave products with high enantioselectivity; therefore, this approach solves a long-standing challenge for imine ATH.
Barrios-Rivera, Jonathan,Xu, Yingjian,Wills, Martin
supporting information
p. 6283 - 6287
(2020/09/02)
Substituted isoquinolines and methods of using same
Novel substituted isoquinoline compounds are disclosed together with novel 2-phenylethylamides useful as precursors or intermediates for the production of the isoquinolines. The substituted isoquinolines exhibit activity in antagonizing the effects of platelet activating factor (PAF).
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(2008/06/13)
Photosolvolysis of bridgehead quaternary ammonium salts. II. Synthesis of some 2,5-benzoxazonine derivatives and attempted synthesis of the 1,2,4,5,6,7-hexahydro-3,5-benzoxazonine system
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Bremner,Winzenberg
p. 1659 - 1676
(2007/10/02)
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