Method for generating ester through reaction of acyl chloride and 1,2-dichloroethane
The invention discloses a method for generating ester through reaction of acyl chloride and 1,2-dichloroethane. The method comprises the following steps: taking acyl chloride, 1,2-dichloroethane and carbonate as reaction substrates, and taking 4-dimethyla
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Paragraph 0023; 0025; 0065; 0066; 0067
(2017/08/30)
An Effective Method for the Construction of Esters Using Cs2CO3 as Oxygen Source
An effective method for the construction of esters from acyl chloride and halohydrocarbon using Cs2CO3 as an oxygen source was achieved for the first time. The methodology has a wide scope of substrates and can be scaled up. The study of a preliminary reaction mechanism demonstrated that the O in the products comes from Cs2CO3 and this esterification proceeds through a free radical reaction. It was also found that CO2 can also be used in this esterification reaction as an oxygen source.
Transition-metal-free aerobic oxidative cleavage of C-C bonds in α-hydroxy ketones and mechanistic insight to the reaction pathway
Clear cut: For the title reaction, O2, the ideal oxidant, was used as the only oxidizing reagent. The dimer intermediate (see scheme) and isotopic labeling control experiments with 18O2 partially disclosed the reaction mec