936074-51-0 Usage
Uses
Used in Medicinal Chemistry:
1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid is used as a building block in the synthesis of novel pharmaceutical agents due to its unique structural features that may confer specific biological activities.
Used in Drug Discovery and Development:
As a research tool, 1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid aids in drug discovery and development processes, providing insights into its potential pharmacological effects and mechanisms of action.
It is crucial for researchers to delve into the properties, potential applications, and safety aspects of 1-(5-Chlorobenzo[d]oxazol-2-yl)piperidine-4-carboxylic acid to ensure its responsible and effective use in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 936074-51-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,6,0,7 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 936074-51:
(8*9)+(7*3)+(6*6)+(5*0)+(4*7)+(3*4)+(2*5)+(1*1)=180
180 % 10 = 0
So 936074-51-0 is a valid CAS Registry Number.
InChI:InChI=1/C13H13ClN2O3/c14-9-1-2-11-10(7-9)15-13(19-11)16-5-3-8(4-6-16)12(17)18/h1-2,7-8H,3-6H2,(H,17,18)
936074-51-0Relevant articles and documents
Novel benzoxazole inhibitors of mPGES-1
Kablaoui, Natasha,Patel, Snahel,Shao, Jay,Demian, Douglas,Hoffmaster, Keith,Berlioz, Francioise,Vazquez, Michael L.,Moore, William M.,Nugent, Richard A.
, p. 907 - 911 (2013/02/25)
A novel series of potent benzoxazole mPGES-1 inhibitors has been derived from a hit from a high throughput screen. Compound 37 displays mPGES-1 inhibition in an enzyme assay (0.018 μM) and PGE-2 inhibition in a cell-based assay (0.034 μM). It demonstrates 500- and 2500-fold selectivity for mPGES-1 over COX-2 and 6-keto PGF-1α, respectively. In vivo PK studies in dogs demonstrate 55% oral bioavailability and an 7 h half-life.
