- A sulfonamide compound intermediates, their salts and method for preparing the same
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The invention discloses compounds as shown in a formula III. The invention also discloses a preparation method of salts of sulfonamide compounds as shown in the formula III, comprising carrying out a coupling reaction for a compound of a formula IV and a compound 2 in a solvent, wherein the temperature is 35-200 DEG C, n2=1-4, and X is a protonic acid which can be removed by distillation under reduced pressure. The invention also discloses a preparation method of sulfonamide compounds as shown in the formula I, inlcuding: (1) preparing a compound of the formula III as the above method; and (2) reacting the compound of the formula III obtained in the step (1) with a base in a solvent with a reflux temperature of 0 DEG C; wherein X is a protonic acid; and n2=1-4. The invention also discloses compounds as shown in the formula IV. The preparation method of the present invention is mild in reaction conditions, high in yield, simple in purification and suitable for industrial production.
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Paragraph 0086-0090
(2017/01/26)
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- COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY
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The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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Page/Page column 129
(2008/12/04)
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- BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES
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The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non receptor kinases.
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Page/Page column 108-109
(2008/06/13)
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