936098-38-3

Basic information

• Product Name: 4-CHLORO-2-IODO-BENZENEACETIC ACID
• Synonyms: 4-CHLORO-2-IODO-BENZENEACETIC ACID
• CAS NO: 936098-38-3
• Molecular Formula: C₈H₆ClIO₂
• Molecular Weight: 296.49
• Mol File: 936098-38-3.mol

Chemical Properties

• Boiling Point: 371.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.964±0.06 g/cm3(Predicted)
• PKA: 3.96±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-IODO-BENZENEACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-IODO-BENZENEACETIC ACID(936098-38-3)
• EPA Substance Registry System: 4-CHLORO-2-IODO-BENZENEACETIC ACID(936098-38-3)

Safety Data

• Hazardous Substances Data: 936098-38-3(Hazardous Substances Data)

Upstream product

• 882689-32-9 4-chloro-1-(chloromethyl)-2-iodobenzene 
• 143-33-9 sodium cyanide 
• 56341-37-8 6-chloro-2-oxindole 
• 13421-13-1 4-chloro-2-iodobenzoic acid 
• 244104-55-0 (4-chloro-2-iodophenyl)methanol 
• 882689-31-8 2-(4-chloro-2-iodophenyl)acetonitrile 

Downstream Products

• 936098-39-4 methyl (4-chloro-2-iodophenyl)acetate 
• 1067882-47-6 2-(4-chloro-2-iodophenyl)ethan-1-ol 
• 936098-52-1 [4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid 
• 936098-44-1 methyl [4-chloro-2-(hydroxymethyl)phenyl]acetate 
• 1159358-87-8 [4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid methyl ester 
• 22482-73-1 5-chloro-2-(2-methoxy-2-oxoethyl)benzoic acid 
• 1301714-83-9 N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-5-chlorophenyl)-6-chloro-4-methyl-1-naphthamide 
• 1301714-70-4 N-butyl-2-(4-chloro-2-ethynylphenyl)acetamide 

Relevant articles and documents

2-Arylacetamides as Versatile Precursors for 3-Aminoisocoumarin and Homophthalimide Derivatives: Palladium-Catalyzed Cascade Double Carbonylation Reactions

The synthesis of biologically relevant homophthalimide and 3-aminoisocoumarin nuclei via palladium-catalyzed carbonylation of 2-(2-iodoaryl)acetamides has been developed. The degree of N-substitution on the starting amide substrate dictates whether C?N or

Zwitterionic CRTh2 antagonists

A novel series of zwitterions is reported that contains potent, selective antagonists of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2). A high quality lead compound 2 was discovered from virtual screening based on the pharmacophore features present in a literature compound 1. Lead optimization through side chain modification and preliminary changes around the acid are disclosed. Optimization of physicochemical properties (log D, MWt, and HBA) allowed maintenance of high CRTh2 potency while achieving low rates of metabolism and minimization of other potential concerns such as hERG channel activity and permeability. A step-change increase in potency was achieved through addition of a single methyl group onto the piperazine ring, which gave high quality compounds suitable for progression into in vivo studies.

Novel Compounds

The invention relates to substituted aryl acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.

HETEROCYCLIC SPIRO-COMPOUNDS

The patent application relates to new heterocyclic compounds of the general formula (I), in which R, R1, R2, Q, T, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.