Chiral Bipyridine Ligand with Flexible Molecular Recognition Site: Development and Application to Copper-Catalyzed Asymmetric Borylation of α,β-Unsaturated Ketones
A novel chiral bipyridine ligand bearing a flexible side chain with a molecular recognition site enables precise stereocontrol through the cooperative action of metal center and hydrogen bonds. This new chiral ligand was applied to the copper-catalyzed as
NOVEL BETA-HYDROXYKETONES AND BETA-ALKOXYKETONES WITH ESTROGENIC ACTIVITY
This invention relates to β-hydroxyketones and β-alkoxyketones of formula (I), to their use as estrogen receptor modulators, and to methods for their preparation.
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(2009/06/27)
Dicationic ((-)-sparteine)palladium-catalyzed enantioselective aldol reaction of aldehydes with 1-phenyl-1-trimethylsilyloxyethene, proceeding via a palladium enolate
A dicationic ((-)-sparteine)palladium complex underwent a superior catalytic enantioselective aldol reaction of aldehydes with 1-phenyl-1-trimethylsilyloxyethene performing satisfactorily, starting with ((-)-sparteine)PdCl2 and AgSbF6/sub
Dicationic (BINAP)palladium-catalyzed enantioselective aldol reaction of aldehydes with a silyl enol ether: a simplified practical procedure
The dicationic ((R)-BINAP)palladium-catalyzed enantioselective aldol reaction of benzaldehyde with 1-phenyl-1-trimethylsilylethene has been reinvestigated regarding the reaction conditions in the presence of ((R)-BINAP)palladium chloride and AgSbF6/
Optically active bidentate phosphine ligand palladium complex
The present invention provides a novel optically active bidentate phosphine ligand palladium complex of formula (I) or (II) which can be used for the preparation of optically active β-hydroxyketones: STR1 ?wherein Y- represents an anion pair wh
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(2008/06/13)
Stable diaqua palladium(II) complexes of BINAP and Tol-BINAP as highly efficient catalysts for asymmetric aldol reactions
The novel chiral diaqua palladium(II) complexes of (R)-BINAP 9a and (R)-Tol-BINAP 9b were prepared in good yield, and their structures were determined by X-ray crystallography. These air-and moisture-stable complexes were found to be excellent catalysts f
HIGHLY ENANTIOSELECTIVE ALDOL REACTION OF METHYL KETONES VIA CHIRAL STANNOUS AZAENOLATES
Chiral 1,3-oxazolidines are readily prepared from methyl ketones and chiral norephedrine.Formation of stannous azaenolates from the oxazolidines and reaction with aldehydes followed by removal of the chiral auxiliary lead to the aldol products in high level of enantiomeric putity.