- Mechanistic switch via subtle ligand modulation: Palladium-catalyzed synthesis of α,β-substituted styrenes via C-H bond functionalization
-
A new catalyst system able to efficiently perform the synthesis of styrenes via C-H bond functionalization and a subtle ligand modification are described. The high level of activity achieved allows for the synthesis of highly functionalized α,β-substituted styrenes, even the elusive E-configured trisubstituted olefins, in a regio- and stereoselective manner. Mechanistic experiments allowed for the identification of the corresponding synthetic intermediates.
- Flores-Gaspar, Areli,Martin, Ruben
-
supporting information; experimental part
p. 1223 - 1228
(2011/06/26)
-
- Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins
-
We report herein a new class of small-molecule inhibitors of antiapoptotic Bcl-2 proteins. The most potent compound, 7, binds to Bcl-2, Bcl-xL, and Mcl-1 proteins with Ki of 110, 638, and 150 nM, respectively. Compound 7 is highly effective in
- Tang, Guozhi,Yang, Chao-Yie,Nikolovska-Coleska, Zaneta,Guo, Jie,Qiu, Su,Wang, Renxiao,Gao, Wei,Wang, Guoping,Stuckey, Jeanne,Krajewski, Krzysztof,Jiang, Sheng,Roller, Peter P.,Wang, Shaomeng
-
p. 1723 - 1726
(2007/10/03)
-