937031-51-1

Basic information

• Product Name: 1,5-anhydro-2-deoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyriMidinyl)-4,6-O-[(R)-phenylMethylene]-D-Altritol
• Synonyms: 1,5-anhydro-2-deoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyriMidinyl)-4,6-O-[(R)-phenylMethylene]-D-Altritol
• CAS NO: 937031-51-1
• Molecular Formula: C₁₇H₁₉N₃O₅
• Molecular Weight: 345.34986
• Mol File: 937031-51-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,5-anhydro-2-deoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyriMidinyl)-4,6-O-[(R)-phenylMethylene]-D-Altritol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-anhydro-2-deoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyriMidinyl)-4,6-O-[(R)-phenylMethylene]-D-Altritol(937031-51-1)
• EPA Substance Registry System: 1,5-anhydro-2-deoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyriMidinyl)-4,6-O-[(R)-phenylMethylene]-D-Altritol(937031-51-1)

Safety Data

• Hazardous Substances Data: 937031-51-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,5-Anhydro-2-deoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-4,6-O-[(R)-phenylmethylene]-D-altritol is used as a potential antiviral agent for its demonstrated activity against various viral infections. Its mechanism of action may involve interference with viral replication processes, thereby limiting the spread of the virus within the host.
1,5-Anhydro-2-deoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-4,6-O-[(R)-phenylmethylene]-D-altritol is also used as an anti-inflammatory agent due to its capacity to modulate inflammatory responses. This property makes it a candidate for the treatment of conditions characterized by excessive or chronic inflammation, which can lead to tissue damage and a range of diseases.
In the context of drug development, PINC is used as a lead compound for the design and synthesis of new pharmaceuticals. Its unique structure provides a foundation for further chemical modifications, potentially enhancing its therapeutic efficacy, selectivity, and reducing side effects.
While the provided materials do not specify particular applications beyond the general realms of antiviral and anti-inflammatory uses, the compound's potential applications in the pharmaceutical industry are vast, given the broad scope of viral infections and inflammatory conditions that impact human health. Further research and development will be crucial to realizing the full potential of 1,5-Anhydro-2-deoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-4,6-O-[(R)-phenylmethylene]-D-altritol in various medical applications.

Upstream product

• 92283-88-0 1,5:2,3-dianhydro-4,6-O-benzylidene-D-allitol 
• 401906-98-7 1′,5′-anhydro-4′,6′-O-benzylidene-2′-deoxy-2′-(uracil-1-yl)-D-altro-hexitol 

Downstream Products

• 227079-07-4 1,5-anhydro-3-O-benzoyl-2-deoxy-2-(N⁴-benzoylcytosin-1-yl)-D-altro-hexitol 
• 227079-08-5 1,5-anhydro-3-O-benzoyl-6-O-monomethoxytrityl-2-deoxy-2-(N⁴-benzoylcytosin-1-yl)-D-altro-hexitol 
• 937031-53-3 1,5-anhydro-4,6-O-benzylidene-2-deoxy-3-O-(9-fluorenylmethoxycarbonyl)-2-[N⁴-(9-fluorenylmethoxycarbonyl)cytosin-1-yl]-D-altro-hexitol 

Relevant articles and documents

Fmoc-protected altritol phosphoramidite building blocks and their application in the synthesis of altritol nucleic acids (ANAs)

Fmoc-protected altritol nucleoside phosphoramidite building blocks with adenine, guanine, thymine, uracil, cytosine and 5-methylcytosine as bases have been synthesized. These building blocks were used for the synthesis of altritol nucleic acid (ANA) and c

Synthesis of protected D-altritol nucleosides as building blocks for oligonucleotide synthesis

D-Altritol nucleosides with an adenine and uracil base moiety were obtained by nucleophilic opening of the epoxide ring of 1,5:2,3-dianhydro- 4,6-O-benzylidene-D-allitol using the sodium salt of the above mentioned bases. The use of a 2-trimethylsilylethyl protecting group for the O6- function of the guanine base offers a useful compromise between stability and acceptable alkylation yields of the N9-position if the guanine base. The cytosine nucleoside was synthesized starting from the uracil congener. The 3'-hydroxyl function was protected with a benzoyl group.