93704-52-0Relevant articles and documents
Synthesis of Substituted Indolobenzodiazepine Derivatives
Hiremath, Shivayogi P.,Hiremath, Dakshayani M.,Purohit, Muralidhar G.
, p. 930 - 933 (2007/10/02)
Various substituted-7,12-dihydroindolobenzodiazepines (4a-e) have been prepared from the corresponding 3-aminoindoles (1a-e) through Ullmann reaction with o-chloroaniline, acylation of the resulting 3-(o-aminophenylamino)indoles (2a-e) and cyclization of amides (3a-e) with POCl3.Similar systems have also been synthesized from ethyl 3-bromoindole-2-carboxylates (6a-e).The bromo esters react with o-phenylenediamine to give ethyl 3-(o-aminophenylamino)indole-2-carboxylates (7a-e) which undergo cyclization in the presence of PPA to yield 5,6,7,12-tetrahydroindolobenzodiazepin-6-ones (8a-e).