- SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER
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Disclosed are compounds of Formula (I) or a salt thereof, wherein Ring A is a carbon-linked ring; and Ring A, R1, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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Page/Page column 81-82
(2021/10/02)
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- TETRAHYDROISOQUINOLINE DERIVATIVES
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The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.
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Page/Page column 70-71
(2016/05/02)
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- DERIVATIVES OF 1-PHENYL-1,5-DIHYDRO-BENZO[B] [1.4]DIAZEPINE-2.4-DIONE AS INHIBITORS OF HIV REPLICATION
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Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.
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- NEODIHYDROTHEBAINE AND BRACTAZONINE, TWO DIBENZAZONINE ALKALOIDS OF PAPAVER BRACTEATUM
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Two new dibenzazonine alkaloids, neodihydrothebaine and bractazonine were isolated from Papaver bracteatum.Their possible biosynthesis from thebaine is discussed.The structures of both new alkaloids are proven by synthesis.An isomeric dibenzazonine compound was also prepared. - Keywords: Papaver bracteatum; Papaveraceae; alkaloids; dibenzazonines; neodihydrothebaine; bractazonine; biosynthetic pathway; synthesis; 5,6,8,9-tetrahydro-2-methoxy-7-methyl-dibenzazonin-1,12-diol; 5,6,8,9-tetrahydro-2,10-dimethoxy-7-methyl-dibenzazonin-1-ol; 5,6,8,9-tetrahydro-2,11-dimethoxy-7-methyl-dibenz-azonin-1-ol; 5,6,8,9-tetrahydro-2,12-dimethoxy-7-methyl-dibenzazonin-1-ol.
- Theuns, Hubert G.,Lenting, Herman B. M.,Salemink, Cornelis A.,Tanaka, Hitoshi,Shibata, Masayoshi,et al.
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p. 1157 - 1166
(2007/10/02)
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