Constructions of tetrahydro-γ-carboline skeletons via intramolecular oxidative carbon-carbon bond formation of enamines
The synthetically and biologically important 4-methyl and 4-methoxy tetrahydro-γ-carboline compounds were readily synthesized in high yields from an aryl amine and a 5-amino-3-oxopentanoate derivative through a series of reactions of enamination, oxidative annulation, deprotection/lactamization and the final reduction reaction of the carbonyl group. The underpinning strategy involves the oxidative C(sp2)-C(sp2) bond formation realized by either Pd(OAc)2/Cu(OAc)2 or a hypervalent iodine reagent.
Lv, Jinglei,Li, Ji,Zhang-Negrerie, Daisy,Shang, Siyun,Gao, Qingzhi,Du, Yunfei,Zhao, Kang
p. 1929 - 1932
(2013/06/04)
Studies directed at a synthesis of the morphine alkaloids. A photochemical approach
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Schultz,Lucci,Napier,et al.
p. 217 - 231
(2007/10/02)
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