937601-36-0

Basic information

• Product Name: METHYL 4-(3-NITRO-2-PYRIDINYL)BENZENECARBOXYLATE
• Synonyms: METHYL 4-(3-NITRO-2-PYRIDINYL)BENZENECARBOXYLATE
• CAS NO: 937601-36-0
• Molecular Formula: C₁₃H₁₀N₂O₄
• Molecular Weight: 258.23
• Mol File: 937601-36-0.mol

Chemical Properties

• Melting Point: 82-84°C
• Appearance: /
• CAS DataBase Reference: METHYL 4-(3-NITRO-2-PYRIDINYL)BENZENECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-(3-NITRO-2-PYRIDINYL)BENZENECARBOXYLATE(937601-36-0)
• EPA Substance Registry System: METHYL 4-(3-NITRO-2-PYRIDINYL)BENZENECARBOXYLATE(937601-36-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 937601-36-0(Hazardous Substances Data)

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 

Relevant articles and documents

Wnt and Hedgehog double-signaling pathway inhibitor and applications thereof

The present invention provides a Wnt and Hedgehog double-signaling pathway inhibitor and applications thereof, particularly a heterocyclic compound having Wnt signaling pathway and Hedgehog signalingpathway inhibitory activity, and a pharmaceutically acceptable salt thereof, wherein the compound has a structure represented by a general formula I defined in the specification. The invention furtherprovides a pharmaceutical composition, which contains a therapeutically effective amount of the heterocyclic compound having Wnt signaling pathway and Hedgehog signaling pathway inhibitory activity,and a pharmaceutically acceptable carrier. The present invention further provides applications of the heterocyclic compound having Wnt signaling pathway and Hedgehog signaling pathway inhibitory activity in preparation of drugs for treatment or prevention of Wnt signaling pathway and Hedgehog signaling pathway abnormalities. According to the present invention, the heterocyclic compound having Wntsignaling pathway and Hedgehog signaling pathway inhibitory activity can inhibit Wnt signaling pathway and Hedgehog signaling pathway so as to improve the diseases caused by Wnt signaling pathway or Hedgehog signaling pathway disorders.

Solvent-free synthesis of δ-carbolines/carbazoles from 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives using DPPE as a reducing agent

A green and efficient preparation of functionalized δ-carbolines/ carbazoles via reductive ring closure by 1,2-bis(dipenylphosphino)ethane under solvent-free conditions is described. The starting materials 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives are readily prepared through Suzuki-Miyaura cross-coupling reaction from commercially available compounds. And the polar by-product ethane-1,2-diylbis(diphenylphosphine oxide) is easily removed from the relatively polar reaction mixture. Various substituted δ-carbolines/carbazoles are obtained in acceptable yields. It is particularly worth mentioning that substrates with electron-withdrawing groups (EWG) also give the desired products in good yield.